Gabrb3, encoding the β3 -subunit of the γ -aminobutyric acid type A (GABA_A) receptor, is crucial for inhibitory function in the nervous system. GABA_A receptors are integral to the GABAergic inhibitory neurotransmission pathway, which is vital for maintaining the balance between neuronal excitation and inhibition in the brain [3].

In Gabrb3 -ablated developing mice, there is a developmental decrease in GABAergic synapses, increased local network synchrony, and enhanced functional connectivity of contralateral pyramidal neuron subtypes. This leads to increased cortical response to tactile stimulation at neonatal stages, revealing its importance in the emergence of interhemispheric circuits for sensory processing [1].

In Gabrb3 endothelial cell-specific knockout (Gabrb3ECKO) mice, there are abnormal blood flow, hypertension, and behavioral deficits, suggesting its role in both brain and heart function [2].

In conclusion, Gabrb3 is essential for inhibitory function in the nervous system and plays a role in the development of interhemispheric circuits for sensory processing. The study of Gabrb3 knockout mouse models has provided insights into its role in neurodevelopmental disorders, epilepsy, and the co-development of psychiatric and cardiac dysfunction [1,2].