C57BL/6JCya-Gabrb3em1flox/Cya
Common Name
Gabrb3-flox
Product ID
S-CKO-02537
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-14402-Gabrb3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Gabrb3-flox Mouse (Catalog S-CKO-02537) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Gabrb3-flox
Strain ID
CKOCMP-14402-Gabrb3-B6J-VA
Gene Name
Product ID
S-CKO-02537
Gene Alias
Cp1, beta3, Gabrb-3, A230092K12Rik
Background
C57BL/6JCya
Gene Full Name
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000039697
NCBI Transcript ID
NM_008071
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Overview of Gene Research
Gabrb3, encoding the β3 -subunit of the γ -aminobutyric acid type A (GABAA) receptor, is crucial for inhibitory function in the nervous system. GABAA receptors are integral to the GABAergic inhibitory neurotransmission pathway, which is vital for maintaining the balance between neuronal excitation and inhibition in the brain [3].
In Gabrb3 -ablated developing mice, there is a developmental decrease in GABAergic synapses, increased local network synchrony, and enhanced functional connectivity of contralateral pyramidal neuron subtypes. This leads to increased cortical response to tactile stimulation at neonatal stages, revealing its importance in the emergence of interhemispheric circuits for sensory processing [1].
In Gabrb3 endothelial cell-specific knockout (Gabrb3ECKO) mice, there are abnormal blood flow, hypertension, and behavioral deficits, suggesting its role in both brain and heart function [2].
In conclusion, Gabrb3 is essential for inhibitory function in the nervous system and plays a role in the development of interhemispheric circuits for sensory processing. The study of Gabrb3 knockout mouse models has provided insights into its role in neurodevelopmental disorders, epilepsy, and the co-development of psychiatric and cardiac dysfunction [1,2].
References：
1. Babij, Rachel, Ferrer, Camilo, Donatelle, Alexander, Liston, Conor, De Marco García, Natalia V. 2022. Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex. In Neuron, 111, 256-274.e10. doi:10.1016/j.neuron.2022.10.037. https://pubmed.ncbi.nlm.nih.gov/36446382/
2. Agrud, Anass, Subburaju, Sivan, Goel, Pranay, Kloner, Robert A, Vasudevan, Anju. 2022. Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction. In Scientific reports, 12, 4922. doi:10.1038/s41598-022-08806-9. https://pubmed.ncbi.nlm.nih.gov/35318369/
3. Feng, Yan, Wei, Zi-Han, Liu, Chao, Zhang, Chu-Chu, Deng, Yan-Chun. 2022. Genetic variations in GABA metabolism and epilepsy. In Seizure, 101, 22-29. doi:10.1016/j.seizure.2022.07.007. https://pubmed.ncbi.nlm.nih.gov/35850019/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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