Adgrg1, also known as GPR56, is an adhesion G protein-coupled receptor. It is involved in various physiological functions such as those of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. It may also be associated with signaling pathways related to cell-cell interaction, migration, and tumor-related processes [1,2]. Genetic models like KO/CKO mouse models can be valuable for studying its functions.

In the context of tumors, ADGRG1/GPR56 has both tumor-suppressive and tumor-promoting functions. For example, in cervical squamous carcinoma, it acts as an oncogene, and knockdown of ADGRG1 suppresses cell proliferation, migration, and invasion, and increases cell sensitivity to cisplatin through the PI3K/Akt/mTOR signaling pathway, suggesting it could be a prognostic marker and therapeutic target [5]. In acute myeloid leukemia, ADGRG1 can serve as a specific marker for tumor-reactive T cells, which may be harnessed for adoptive cell therapy and tumor-reactive TCR enrichment [3]. In trophoblast giant cell differentiation, Adgrg1 is a transcriptional target of Hand1, and its knockdown affects Prl2c2 expression as well as cell migration and invasion, indicating a potential role in placental-associated diseases [4].

In conclusion, Adgrg1 is a versatile adhesion G protein-coupled receptor with important functions in multiple physiological and pathological processes. The use of KO/CKO mouse models in research could further elucidate its role in diseases such as tumors and placental-related disorders, providing insights for potential therapeutic strategies.