C57BL/6JCya-Ktn1em1flox/Cya
Common Name:
Ktn1-flox
Product ID:
S-CKO-03330
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ktn1-flox
Strain ID
CKOCMP-16709-Ktn1-B6J-VA
Gene Name
Product ID
S-CKO-03330
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
14
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ktn1em1flox/Cya mice (Catalog S-CKO-03330) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022391
NCBI RefSeq
NM_008477
Target Region
Exon 3~4
Size of Effective Region
~3.9 kb
Detailed Document
Overview of Gene Research
Ktn1, known as kinectin 1, is associated with various biological processes and diseases. It has been implicated in pathways such as cell cycle, DNA replication, and microRNAs in cancer [1]. In normal physiological processes, it may play a role in cell survival, migration, and invasion, as well as in the regulation of cell cycle and apoptosis. Genetic models can be valuable for studying its function.
In hepatocellular carcinoma (HCC), Ktn1 expression is increased, and high expression is correlated with poorer prognosis. Knockout of Ktn1 in Huh7 cells inhibited the viability, migration, and invasion ability of HCC cells, increased the proportion of cells in the G0-G1 phases, and elevated apoptosis rates [1]. In attention deficit hyperactivity disorder (ADHD), Ktn1 variants were significantly associated with the disorder, and the major alleles of risk variants increased putamen volumes [2]. In Parkinson's disease (PD), certain Ktn1 variants increased the risk for PD and putamen gray matter volumes, and also increased Ktn1 mRNA expression in the putamen or substantia nigra pars compacta [3].
In conclusion, Ktn1 plays important roles in cell survival, migration, invasion, cell cycle, and apoptosis as revealed through functional studies. Gene knockout models in HCC, ADHD, and PD have helped uncover its contributions to these disease areas, indicating its potential as a therapeutic target in HCC, and highlighting its role in the development of ADHD and PD.
References:
1. Pan, Jian, Chao, Nai-Xia, Zhang, Yao-Yao, Huang, Rong-Shi, Luo, Guo-Rong. 2021. Upregulating KTN1 promotes Hepatocellular Carcinoma progression. In Journal of Cancer, 12, 4791-4809. doi:10.7150/jca.55570. https://pubmed.ncbi.nlm.nih.gov/34234850/
2. Luo, Xingguang, Guo, Xiaoyun, Tan, Yunlong, Wang, Kesheng, Li, Chiang-Shan R. 2020. KTN1 variants and risk for attention deficit hyperactivity disorder. In American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 183, 234-244. doi:10.1002/ajmg.b.32782. https://pubmed.ncbi.nlm.nih.gov/32190980/
3. Mao, Qiao, Wang, Xiaoping, Chen, Bin, Li, Chiang-Shan R, Luo, Xingguang. 2020. KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson's Disease. In Frontiers in neuroscience, 14, 651. doi:10.3389/fnins.2020.00651. https://pubmed.ncbi.nlm.nih.gov/32655362/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen