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C57BL/6JCya-Havcr1em1flox/Cya
Common Name:
Havcr1-flox
Product ID:
S-CKO-03615
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Havcr1-flox
Strain ID
CKOCMP-171283-Havcr1-B6J-VA
Gene Name
Havcr1
Product ID
S-CKO-03615
Gene Alias
KIM-1; TIM-1; Tim1; Timd1
Background
C57BL/6JCya
NCBI ID
171283
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:2159680
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Havcr1em1flox/Cya mice (Catalog S-CKO-03615) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000047568
NCBI RefSeq
NM_134248
Target Region
Exon 2~3
Size of Effective Region
~4.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Havcr1, also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) and hepatitis A virus cellular receptor 1, is a type-1 integral membrane glycoprotein. It has a key role in immunity, renal regeneration, and acts as a receptor for hepatitis A virus [4,6]. It may also be involved in cancer-associated signaling pathways [5]. Genetic models, such as gene knockout in mice, are valuable for studying its functions.

In B cells, selective deletion of Havcr1 substantially inhibited tumour growth and enhanced effector T cell responses in a B16F10 melanoma mouse model. Loss of TIM-1 enhanced the type 1 interferon response in B cells, leading to increased B cell activation, antigen presentation, and co-stimulation, ultimately promoting the expansion of tumour-specific effector T cells [1]. In a high-fat-fed streptozotocin mouse model of diabetic kidney disease (DKD), genetic ablation of the KIM-1 (a product of Havcr1) mucin domain ameliorated tubule injury associated with DKD [2]. Placenta-specific Havcr1 deletion in mice significantly impaired Zika virus (ZIKV) transplacental transmission and associated adverse pregnancy outcomes, highlighting its role in ZIKV vertical transmission [3].

In conclusion, Havcr1 is crucial in multiple biological processes and disease conditions. Gene knockout mouse models have revealed its role in anti-tumour immunity, DKD, and ZIKV vertical transmission. These findings contribute to understanding the pathogenesis of related diseases and may provide potential therapeutic targets.

References:
1. Bod, Lloyd, Kye, Yoon-Chul, Shi, Jingwen, Regev, Aviv, Kuchroo, Vijay K. 2023. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. In Nature, 619, 348-356. doi:10.1038/s41586-023-06231-0. https://pubmed.ncbi.nlm.nih.gov/37344597/
2. Mori, Yutaro, Ajay, Amrendra K, Chang, Jae-Hyung, Ichimura, Takaharu, Bonventre, Joseph V. . KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. In Cell metabolism, 33, 1042-1061.e7. doi:10.1016/j.cmet.2021.04.004. https://pubmed.ncbi.nlm.nih.gov/33951465/
3. Yu, Wenzhe, Tao, Jun, Cao, Hongmin, Hu, Xiaoqian, Cao, Bin. 2025. The HAVCR1-centric host factor network drives Zika virus vertical transmission. In Cell reports, 44, 115464. doi:10.1016/j.celrep.2025.115464. https://pubmed.ncbi.nlm.nih.gov/40156834/
4. Liu, Sheng, Tang, Wenting, Cao, Jing, Gong, Jiao, Hu, Bo. 2022. A Comprehensive Analysis of HAVCR1 as a Prognostic and Diagnostic Marker for Pan-Cancer. In Frontiers in genetics, 13, 904114. doi:10.3389/fgene.2022.904114. https://pubmed.ncbi.nlm.nih.gov/35754803/
5. Li, Guangyao, Javed, Muhammad, Rasool, Rubab, Aufy, Mohammed, Cao, Kun. 2023. A pan-cancer analysis of HAVCR1 with a focus on diagnostic, prognostic and immunological roles in human cancers. In American journal of translational research, 15, 1590-1606. doi:. https://pubmed.ncbi.nlm.nih.gov/37056808/
6. Costafreda, Maria Isabel, Kaplan, Gerardo. 2018. HAVCR1 (CD365) and Its Mouse Ortholog Are Functional Hepatitis A Virus (HAV) Cellular Receptors That Mediate HAV Infection. In Journal of virology, 92, . doi:10.1128/JVI.02065-17. https://pubmed.ncbi.nlm.nih.gov/29437974/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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