Ntrk1, also known as Neurotrophic tyrosine kinase receptor 1, is a receptor tyrosine kinase. It is the high-affinity receptor for Nerve Growth Factor and plays a crucial role in regulating neural development and differentiation. Its activity is involved in multiple pathways such as the AMPK/ULK1/FUNDC1 pathway, and deregulation is associated with several human disorders [2]. Genetic models, like knockout mouse models, are valuable for studying its functions.

In a mouse Ntrk1-knockdown model, Ntrk1 knockdown led to cognitive impairment and hippocampal neuronal damage. This was due to the suppression of mitophagy via inactivating the AMPK/ULK1/FUNDC1 pathway. Treatment with BAY-3827 exacerbated depressive-like behavior, while pre-treatment with O304 and rapamycin abrogated the negative effects on mitophagy and neuronal damage [1].

In conclusion, Ntrk1 is essential for maintaining normal neuronal function, especially in the hippocampus, as revealed by the Ntrk1-knockdown mouse model. Understanding its role through such models provides insights into the development of novel strategies for treating cognitive impairment caused by hippocampal neuronal damage.