C57BL/6JCya-Ntrk1em1flox/Cya
Common Name
Ntrk1-flox
Product ID
S-CKO-04044
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18211-Ntrk1-B6J-VA
When using this mouse strain in a publication, please cite “Ntrk1-flox Mouse (Catalog S-CKO-04044) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ntrk1-flox
Strain ID
CKOCMP-18211-Ntrk1-B6J-VA
Gene Name
Product ID
S-CKO-04044
Gene Alias
Tkr, trk, TrkA
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000029712
NCBI RefSeq
NM_001033124
Target Region
Exon 4~6
Size of Effective Region
~2.7 kb
Overview of Gene Research
Ntrk1, also known as Neurotrophic tyrosine kinase receptor 1, is a receptor tyrosine kinase. It is the high-affinity receptor for Nerve Growth Factor and plays a crucial role in regulating neural development and differentiation. Its activity is involved in multiple pathways such as the AMPK/ULK1/FUNDC1 pathway, and deregulation is associated with several human disorders [2]. Genetic models, like knockout mouse models, are valuable for studying its functions.
In a mouse Ntrk1-knockdown model, Ntrk1 knockdown led to cognitive impairment and hippocampal neuronal damage. This was due to the suppression of mitophagy via inactivating the AMPK/ULK1/FUNDC1 pathway. Treatment with BAY-3827 exacerbated depressive-like behavior, while pre-treatment with O304 and rapamycin abrogated the negative effects on mitophagy and neuronal damage [1].
In conclusion, Ntrk1 is essential for maintaining normal neuronal function, especially in the hippocampus, as revealed by the Ntrk1-knockdown mouse model. Understanding its role through such models provides insights into the development of novel strategies for treating cognitive impairment caused by hippocampal neuronal damage.
References：
1. Yang, Kai, Wu, Jue, Li, Shang, Yuan, Jun-Liang, Yin, Cheng-Hong. 2023. NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway. In Cell death discovery, 9, 404. doi:10.1038/s41420-023-01685-7. https://pubmed.ncbi.nlm.nih.gov/37907480/
2. Pierotti, Marco A, Greco, Angela. 2005. Oncogenic rearrangements of the NTRK1/NGF receptor. In Cancer letters, 232, 90-8. doi:. https://pubmed.ncbi.nlm.nih.gov/16242838/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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