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C57BL/6JCya-Prkcbem1flox/Cya
Common Name:
Prkcb-flox
Product ID:
S-CKO-04302
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Prkcb-flox
Strain ID
CKOCMP-18751-Prkcb-B6J-VA
Gene Name
Prkcb
Product ID
S-CKO-04302
Gene Alias
PKC-B; PKC-Beta; Pkcb; Prkcb1; Prkcb2
Background
C57BL/6JCya
NCBI ID
18751
Modification
Conditional knockout
Chromosome
7
Phenotype
MGI:97596
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Prkcbem1flox/Cya mice (Catalog S-CKO-04302) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000064989
NCBI RefSeq
NM_008855
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Prkcb, Protein kinase C beta, is a member of the classical PRKCs. It plays a role in negatively modulating the mitochondrial energy status and inhibiting autophagy [6]. It is also involved in pathways like T cell receptor-NF-κB signaling and T cell trafficking, as well as immunosurveillance [5].

In lung adenocarcinoma (LUAD), Prkcb expression is related to prognosis through methylation and immune infiltration. It is lowly expressed in LUAD patients and involved in cancer-related Kyoto Encyclopedia of Genes and Genomes pathway and immune infiltration [1]. In Ewing sarcoma, Prkcb is significantly overexpressed and its immunohistochemistry is sensitive and specific for diagnosing Ewing sarcoma with EWSR1 rearrangement [2].

In intestinal ischemia/reperfusion, a circRNA transcribed from the Prkcb gene, circ-Prkcb, acts as an endogenous miR-339-5p sponge to regulate p66Shc expression, which is related to oxidative stress [3]. In the study of crosstalk between periodontitis and osteoporosis, Prkcb was identified as a key gene involved in neutrophil extracellular trap formation and MAPK signaling pathway [4]. In Nano NiO-induced collagen formation in BEAS-2B cells, Prkcb DNA methylation is regulated by lncRNA AP000487.1, affecting the TLR4/MyD88/NF-κB pathway [7]. Zuojin capsule may inhibit colorectal cancer by targeting Prkcb [8].

In conclusion, Prkcb plays essential roles in various biological processes and diseases. Studies on Prkcb contribute to understanding the mechanisms of autophagy, tumorigenesis, oxidative stress, and the crosstalk between different diseases. The findings from different research models help to explore potential biomarker and therapeutic targets related to Prkcb in multiple disease areas.

References:
1. Wang, Jinjie, Shi, Muqi, Zhang, Haijian, Zhou, Youlang, Shi, Jiahai. 2022. PRKCB is relevant to prognosis of lung adenocarcinoma through methylation and immune infiltration. In Thoracic cancer, 13, 1837-1849. doi:10.1111/1759-7714.14466. https://pubmed.ncbi.nlm.nih.gov/35567329/
2. Zota, Victor, Siegal, Gene P, Kelly, David, Magliocco, Anthony, Bui, Marilyn M. 2022. Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing Sarcoma. In Fetal and pediatric pathology, 42, 241-252. doi:10.1080/15513815.2022.2117579. https://pubmed.ncbi.nlm.nih.gov/36062956/
3. Feng, Dongcheng, Wang, Zhecheng, Zhao, Yan, Yao, Jihong, Tian, Xiaofeng. 2020. circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion. In Theranostics, 10, 10680-10696. doi:10.7150/thno.44250. https://pubmed.ncbi.nlm.nih.gov/32929374/
4. Liu, Jia, Zhang, Ding, Cao, Yu, Ye, Surong, Yang, Luyi. 2022. Screening of crosstalk and pyroptosis-related genes linking periodontitis and osteoporosis based on bioinformatics and machine learning. In Frontiers in immunology, 13, 955441. doi:10.3389/fimmu.2022.955441. https://pubmed.ncbi.nlm.nih.gov/35990678/
5. Kataoka, Keisuke, Nagata, Yasunobu, Kitanaka, Akira, Shimoda, Kazuya, Ogawa, Seishi. 2015. Integrated molecular analysis of adult T cell leukemia/lymphoma. In Nature genetics, 47, 1304-15. doi:10.1038/ng.3415. https://pubmed.ncbi.nlm.nih.gov/26437031/
6. Patergnani, Simone, Marchi, Saverio, Rimessi, Alessandro, Mehta, Kamal D, Pinton, Paolo. 2013. PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy. In Autophagy, 9, 1367-85. doi:10.4161/auto.25239. https://pubmed.ncbi.nlm.nih.gov/23778835/
7. Zheng, Jinfa, Wang, Jinyu, Li, Kun, Chang, Xuhong, Sun, Yingbiao. 2023. LncRNA AP000487.1 regulates PRKCB DNA methylation-mediated TLR4/MyD88/NF-κB pathway in Nano NiO-induced collagen formation in BEAS-2B cells. In Environmental toxicology, 38, 2783-2796. doi:10.1002/tox.23918. https://pubmed.ncbi.nlm.nih.gov/37528634/
8. Fan, Jin-Hua, Xu, Min-Min, Zhou, Li-Ming, Li, Xue-Gang, Ye, Xiao-Li. 2021. Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer. In Phytomedicine : international journal of phytotherapy and phytopharmacology, 96, 153881. doi:10.1016/j.phymed.2021.153881. https://pubmed.ncbi.nlm.nih.gov/34942456/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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