Sftpd, which encodes surfactant protein D, is a gene of significance in multiple biological processes. Surfactant protein D is a pattern recognition molecule belonging to the collectin family, expressed in multiple human organ systems including the lungs. It is involved in surfactant metabolism, and may play a role in immune-related processes, cell-cell communication, and chemokine signaling pathways [1].

In a study on lung metastatic colorectal cancer, Sftpd was identified as one of the hub genes. Its expression was found to facilitate cellular proliferation and lung metastasis in colorectal cancer, suggesting its potential role in cancer metastasis [1].

In a gene deletion study of Sftpd-/-mice, initial observations of visual impairment and retinal thinning were later found to be due to an unrecognized Pde6brd1 genotype from earlier breeding, indicating that loss of Sftpd alone does not result in retinal degeneration [2].

In paediatric inflammatory bowel disease, the SFTPD gene was seemingly associated with age at first immunosuppression, suggesting its potential link to disease severity [3].

In lung adenocarcinoma, low expression of Sftpd promoted cancer cell proliferation and tumor-associated M2 macrophage polarization [4].

In conclusion, Sftpd plays important roles in various biological processes and disease conditions. Studies using gene-knockout mouse models and human-based research have provided insights into its functions in cancer metastasis, inflammatory bowel disease, and lung-related diseases. Understanding the role of Sftpd may offer new perspectives for the diagnosis, prognosis, and treatment of these diseases.