C57BL/6JCya-Tifaem1flox/Cya
Common Name
Tifa-flox
Product ID
S-CKO-05586
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-211550-Tifa-B6J-VA
When using this mouse strain in a publication, please cite “Tifa-flox Mouse (Catalog S-CKO-05586) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tifa-flox
Strain ID
CKOCMP-211550-Tifa-B6J-VA
Gene Name
Product ID
S-CKO-05586
Gene Alias
T2bp
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000054483
NCBI RefSeq
NM_145133
Target Region
Exon 3
Size of Effective Region
~2.9 kb
Overview of Gene Research
TIFA, the Tumor necrosis factor receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain, is an important regulator in innate immune signaling. It operates via regulating TRAF proteins, playing a role in processes like inflammation, hematopoiesis, and is involved in multiple signaling pathways such as ALPK1/TIFA/TRAF6 pathway [1,2].
TIFA has been shown to have diverse roles in different diseases. In colorectal cancer, its knockdown inhibited cell proliferation [4]. In sepsis-induced acute kidney injury, TIFA induced pyroptosis by activating mitochondrial damage [3]. In pulmonary arterial hypertension, TIFA protein expression was associated with the disease and could independently predict its presence [5]. In glioma, TIFA promoted proliferation, migration, and glycolysis through regulating E2F1 [6].
In conclusion, TIFA is a crucial mediator in innate immune responses and inflammation-related processes. Studies on TIFA using gene-related models help to understand its role in various diseases, such as colorectal cancer, sepsis-induced kidney injury, pulmonary arterial hypertension, and glioma, which may provide potential therapeutic targets for these diseases.
References：
1. Niederkorn, Madeline, Agarwal, Puneet, Starczynowski, Daniel T. 2020. TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease. In Experimental hematology, 90, 18-29. doi:10.1016/j.exphem.2020.08.010. https://pubmed.ncbi.nlm.nih.gov/32910997/
2. Martin-Gallausiaux, Camille, Salesse, Laurène, Garcia-Weber, Diego, Arrieumerlou, Cécile, Lapaque, Nicolas. 2023. Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation. In Gut microbes, 16, 2295384. doi:10.1080/19490976.2023.2295384. https://pubmed.ncbi.nlm.nih.gov/38126163/
3. Li, Yiming, Zhang, Jing, Zhai, Pan, Liu, Chang, Peng, Zhiyong. 2022. The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury. In International immunopharmacology, 115, 109580. doi:10.1016/j.intimp.2022.109580. https://pubmed.ncbi.nlm.nih.gov/36586274/
4. Shen, Wenzhi, Du, Wenfei, Li, Yanping, Zhang, Xiaoyuan, Zhang, Zhixin. 2022. TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner. In Cancer science, 113, 3018-3031. doi:10.1111/cas.15432. https://pubmed.ncbi.nlm.nih.gov/35635239/
5. Chang, Hao-Chih, Wei, Tong-You Wade, Wu, Pei-Yu, Chen, Chen-Huan, Sung, Shih-Hsien. 2021. TIFA protein expression is associated with pulmonary arterial hypertension. In Scientific reports, 11, 14140. doi:10.1038/s41598-021-93582-1. https://pubmed.ncbi.nlm.nih.gov/34238983/
6. Liu, Zhibing, He, Miaolong, Yu, Zeshun, Wang, Xiuwen, Ning, Fangling. 2024. TIFA enhances glycolysis through E2F1 and promotes the progression of glioma. In Cellular signalling, 125, 111498. doi:10.1016/j.cellsig.2024.111498. https://pubmed.ncbi.nlm.nih.gov/39481822/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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