C57BL/6JCya-Tmem71em1flox/Cya
Common Name:
Tmem71-flox
Product ID:
S-CKO-05684
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Tmem71-flox
Strain ID
CKOCMP-213068-Tmem71-B6J-VA
Gene Name
Product ID
S-CKO-05684
Gene Alias
E430024D12
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tmem71em1flox/Cya mice (Catalog S-CKO-05684) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000048372
NCBI RefSeq
NM_172514
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Tmem71, Transmembrane protein 71, is implicated in multiple cellular physiological functions. It has been associated with immune and inflammatory responses, cell proliferation, cell migration, chemotaxis, and response to drugs [2]. It may be involved in the JAK2/STAT3 and NLRP3/Caspase-1/GSDMD signaling pathways [1,3].
In glioma, high expression of Tmem71 is correlated with poor prognosis, and it may function as an oncogene, promoting the growth and motility of glioma cells by activating the JAK2/STAT3 pathway and promoting CEBPD expression [1,2]. In nasopharyngeal carcinoma, Tmem71 is downregulated in tumor tissues, and its overexpression could exert anticancer effects via the NLRP3/caspase-1/GSDMD pathway [3]. In breast cancer, Tmem71 is downregulated, and its overexpression suppresses cell proliferation and migration [4].
In conclusion, Tmem71 plays a significant role in the development and progression of various cancers, with its abnormal expression being linked to tumor prognosis and cell behavior. The study of Tmem71 in these cancer models provides insights into its function in disease, potentially guiding the development of new therapeutic strategies.
References：
1. Xie, Jiabao, Yu, Wanli, Gui, Shikai, Luo, Haitao, Cheng, Zujue. 2025. TMEM71 is crucial for cell proliferation in lower-grade glioma and is linked to unfavorable prognosis. In Cancer cell international, 25, 109. doi:10.1186/s12935-025-03747-5. https://pubmed.ncbi.nlm.nih.gov/40119335/
2. Wang, Kuan-Yu, Huang, Ruo-Yu, Tong, Xue-Zhi, Hu, Hui-Min, Jiang, Tao. 2019. Molecular and clinical characterization of TMEM71 expression at the transcriptional level in glioma. In CNS neuroscience & therapeutics, 25, 965-975. doi:10.1111/cns.13137. https://pubmed.ncbi.nlm.nih.gov/31180187/
3. Liu, Dan, Liu, Yuanzhou, Cen, Ruixiang. 2025. Identification of TMEM71 as a hub NLRP3-related gene suppressing malignant behavior in nasopharyngeal carcinoma via the NLRP3/Caspase-1/GSDMD signaling pathway. In Brazilian journal of otorhinolaryngology, 91, 101566. doi:10.1016/j.bjorl.2025.101566. https://pubmed.ncbi.nlm.nih.gov/39951856/
4. Li, Wenhao, Wang, Xiaolong, Li, Chen, Li, Zheng, Yang, Qifeng. 2022. Identification and validation of an m6A-related gene signature to predict prognosis and evaluate immune features of breast cancer. In Human cell, 36, 393-408. doi:10.1007/s13577-022-00826-x. https://pubmed.ncbi.nlm.nih.gov/36403174/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen