C57BL/6JCya-Tex9em1flox/Cya
Common Name:
Tex9-flox
Product ID:
S-CKO-06196
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Tex9-flox
Strain ID
CKOCMP-21778-Tex9-B6J-VA
Gene Name
Product ID
S-CKO-06196
Gene Alias
Gm19407; tsec-1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tex9em1flox/Cya mice (Catalog S-CKO-06196) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000184125
NCBI RefSeq
NM_009359
Target Region
Exon 8~9
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Tex9, or Testis-expressed protein 9, is a gene with diverse functions. It has been associated with cilia-related processes as its cilia/basal body localization was experimentally confirmed, and it may be involved in ciliogenesis/flagellum formation in germ cells [3,5].
In esophageal squamous cell carcinoma (ESCC), TEX9 expression was found to be positively associated with eIF3b expression and positively correlated with TNM stage. TEX9 and eIF3b functionally synergize to promote the proliferation and migration, and inhibit the apoptosis of ESCC cells through the activation of AKT signaling pathway [1].
In a Drosophila model, the knockdown of TEX9 resulted in normal fertility, indicating that TEX9 may not be essential for male fertility in this model [2].
In a syngeneic triple-negative breast cancer (TNBC) model, Tex9 was identified as one of the genes that selectively regulated adaptive anti-tumor immunity, demonstrating its impact on anti-tumor immunity [4].
In conclusion, Tex9 has functions in ciliary processes, cancer progression, and anti-tumor immunity. The studies in different models, such as Drosophila and mouse models, have provided insights into its role in specific biological processes and disease conditions, highlighting its importance in understanding ciliary-related functions and cancer-related mechanisms.
References：
1. Xu, Fengkai, Zhang, Shu, Liu, Zhonghe, Ge, Di, Lu, Chunlai. 2019. TEX9 and eIF3b functionally synergize to promote the progression of esophageal squamous cell carcinoma. In BMC cancer, 19, 875. doi:10.1186/s12885-019-6071-9. https://pubmed.ncbi.nlm.nih.gov/31481019/
2. Sieper, Marie H, Gaikwad, Avinash S, Fros, Marion, Tüttelmann, Frank, Wyrwoll, Margot J. 2023. Scrutinizing the human TEX genes in the context of human male infertility. In Andrology, 12, 570-584. doi:10.1111/andr.13511. https://pubmed.ncbi.nlm.nih.gov/37594251/
3. Nevers, Yannis, Prasad, Megana K, Poidevin, Laetitia, Poch, Olivier, Lecompte, Odile. . Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling. In Molecular biology and evolution, 34, 2016-2034. doi:10.1093/molbev/msx146. https://pubmed.ncbi.nlm.nih.gov/28460059/
4. Shuptrine, Casey W, Ajina, Reham, Fertig, Elana J, Hartman, Zachary C, Weiner, Louis M. 2017. An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. In Cancer immunology, immunotherapy : CII, 66, 1529-1544. doi:10.1007/s00262-017-2047-2. https://pubmed.ncbi.nlm.nih.gov/28770278/
5. Vandenbrouck, Yves, Pineau, Charles, Lane, Lydie. 2020. The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology. In Journal of proteome research, 19, 4782-4794. doi:10.1021/acs.jproteome.0c00516. https://pubmed.ncbi.nlm.nih.gov/33064489/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen