C57BL/6JCya-Trfem1flox/Cya
Common Name
Trf-flox
Product ID
S-CKO-06443
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-22041-Trf-B6J-VA
When using this mouse strain in a publication, please cite “Trf-flox Mouse (Catalog S-CKO-06443) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Trf-flox
Strain ID
CKOCMP-22041-Trf-B6J-VA
Gene Name
Product ID
S-CKO-06443
Gene Alias
Cd176, HP, Tf, Tfn, hpx
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000035158
NCBI RefSeq
NM_133977.2
Target Region
Exon 3~5
Size of Effective Region
~2.6 kb
Overview of Gene Research
Trf, also known as T cell-replacing factor, is a T-cell-derived lymphokine. It triggers activated B cells for terminal differentiation into Ig-secreting cells, exerts BCGF II activity, and induces the expression of IL-2 receptors. It is involved in B-cell growth and differentiation processes, playing an important role in the immune-related biological pathways [3].
In recent studies, tRNA-derived fragments (tRFs, a different entity from Trf but relevant in the provided references) have shown diverse functions. For example, tRF-3022b in colorectal cancer affects tumor growth and M2 macrophage polarization by binding to cytokines like galectin 1 and macrophage migration inhibitory factor [1]. tRF-16-7X9PN5D promotes the radiation resistance of colorectal cancer cells by targeting MKNK1 [2]. These studies on tRFs, though not directly on Trf, provide an example of how non-coding RNAs can be involved in disease-related biological processes, which may be relevant for understanding Trf's role in immune-related diseases.
In conclusion, Trf is crucial for B-cell differentiation and growth, playing a significant role in the immune system. Although the provided references mainly focus on tRFs, they give insights into the importance of non-coding RNAs in disease, which may help in further research on Trf and its potential implications in immune-related diseases.
References：
1. Lu, Sicheng, Wei, Xiaoman, Tao, Lihuiping, Sun, Dongdong, Cheng, Haibo. 2022. A novel tRNA-derived fragment tRF-3022b modulates cell apoptosis and M2 macrophage polarization via binding to cytokines in colorectal cancer. In Journal of hematology & oncology, 15, 176. doi:10.1186/s13045-022-01388-z. https://pubmed.ncbi.nlm.nih.gov/36527118/
2. Huang, Tianyi, Chen, Chujia, Du, Juan, Fang, Shuai, Liu, Kaitai. 2023. A tRF-5a fragment that regulates radiation resistance of colorectal cancer cells by targeting MKNK1. In Journal of cellular and molecular medicine, 27, 4021-4033. doi:10.1111/jcmm.17982. https://pubmed.ncbi.nlm.nih.gov/37864471/
3. Takatsu, K, Tominaga, A, Harada, N, Kikuchi, Y, Yamaguchi, N. . T cell-replacing factor (TRF)/interleukin 5 (IL-5): molecular and functional properties. In Immunological reviews, 102, 107-35. doi:. https://pubmed.ncbi.nlm.nih.gov/3284812/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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