Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Dapem1flox/Cya
Common Name:
Dap-flox
Product ID:
S-CKO-06603
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Dap-flox
Strain ID
CKOCMP-223453-Dap-B6J-VA
Gene Name
Dap
Product ID
S-CKO-06603
Gene Alias
4921531N22Rik
Background
C57BL/6JCya
NCBI ID
223453
Modification
Conditional knockout
Chromosome
15
Phenotype
MGI:1918190
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dapem1flox/Cya mice (Catalog S-CKO-06603) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000044524
NCBI RefSeq
NM_146057
Target Region
Exon 3~4
Size of Effective Region
~3.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Dap can refer to multiple entities. In the context of genes, DAP-kinase (Death-associated protein kinase) is a calcium/calmodulin-dependent serine/threonine kinase. It participates in various apoptosis systems, and is a tumor suppressor mediating cell death pathways like apoptosis and programmed necrosis. It is also identified as an essential regulator of autophagy, activated by signals such as cytokines and ER stress [1].

Functional studies suggest that DAP-kinase may direct autophagy specifically towards autophagic cell death. It has been mapped to distinct stages in autophagy signaling, including the Beclin-1/phosphatidylinositol 3-kinase (PI(3)K) complex necessary for autophagosome formation, and an interaction with the LC3 binding protein, MAP1B, which may regulate vesicle trafficking [1]. Additionally, DAP-kinase suppresses integrin-mediated cell adhesion and signal transduction, and this adhesion-inhibitory effect accounts for a major mechanism of the apoptosis it induces. It exerts apoptotic effects by suppressing integrin functions and integrin-mediated survival signals, thereby activating a p53-dependent apoptotic pathway [2]. Also, loss of DAP-kinase expression provides a mechanism that links suppression of apoptosis to metastasis. Restoration of DAP-kinase to physiological levels in high-metastatic Lewis carcinoma cells suppressed their ability to form lung metastases and delayed local tumour growth [3].

In conclusion, DAP-kinase is crucial in regulating apoptosis, autophagy, and metastasis. Studies on DAP-kinase, especially through in vivo models like the ones using Lewis carcinoma cells, have revealed its role in cancer-related processes. Understanding DAP-kinase provides insights into the mechanisms of cell death and metastasis, which could potentially lead to new strategies for cancer treatment.

References:
1. Bialik, Shani, Kimchi, Adi. 2009. Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy. In Current opinion in cell biology, 22, 199-205. doi:10.1016/j.ceb.2009.11.004. https://pubmed.ncbi.nlm.nih.gov/20005690/
2. Wang, Won-Jing, Kuo, Jean-Cheng, Yao, Chung-Chen, Chen, Ruey-Hwa. 2002. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. In The Journal of cell biology, 159, 169-79. doi:. https://pubmed.ncbi.nlm.nih.gov/12370243/
3. Inbal, B, Cohen, O, Polak-Charcon, S, Eisenbach, L, Kimchi, A. . DAP kinase links the control of apoptosis to metastasis. In Nature, 390, 180-4. doi:. https://pubmed.ncbi.nlm.nih.gov/9367156/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest