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C57BL/6JCya-Trpv2em1flox/Cya
Common Name:
Trpv2-flox
Product ID:
S-CKO-06637
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Trpv2-flox
Strain ID
CKOCMP-22368-Trpv2-B6J-VA
Gene Name
Trpv2
Product ID
S-CKO-06637
Gene Alias
GRC; OTRPC2; VRL-1; Vrl1
Background
C57BL/6JCya
NCBI ID
22368
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:1341836
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Trpv2em1flox/Cya mice (Catalog S-CKO-06637) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000018651
NCBI RefSeq
NM_011706
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Trpv2, or Transient Receptor Potential Vanilloid type 2, is a calcium-permeable cation channel belonging to the TRPV channel family. It is activated by heat (>52 °C), various ligands, and mechanical stresses. Under unstimulated conditions, a large portion of it is located in the endoplasmic reticulum, and upon certain stimulations like phosphatidylinositol 3-kinase-activating ligands or mechanical stress, it translocates to the plasma membrane to function as a cation channel. It is highly expressed in neurons, neuroendocrine cells, immune cells involved in innate immunity, and certain cancer cells, modulating various cellular functions [1].

In B cells, TRPV2 is highly expressed and plays a crucial role in the formation of the B cell immunological synapse and B cell activation. Mice with deficient TRPV2 in B cells display impaired antibody responses following immunization, indicating its importance in B cell-mediated immune functions [2]. In the context of heart failure and muscular dystrophy-related cardiomyopathy, TRPV2 is a stretch-sensitive channel that causes sustained intracellular Ca2+ increase in muscular cells. Inactivation of TRPV2 in animal models of cardiomyopathy with heart failure ameliorates muscle dysgenesis, improves cardiac function, and survival prognosis [3,4]. Regarding viral infections, the interferon-stimulated gene TRIM21 interacts with and degrades TRPV2 in myeloid cells. Trim21-/-mice are more susceptible to HSV-1 and VSV infection, and this susceptibility is rescued by inhibition or deletion of TRPV2 [5].

In conclusion, Trpv2 is a key ion channel involved in multiple biological processes. Its role in B cell activation, heart failure, muscular dystrophy-related cardiomyopathy, and viral infections has been revealed through gene-knockout or conditional-knockout mouse models. Understanding Trpv2 function provides potential therapeutic targets for related diseases.

References:
1. Kojima, Itaru, Nagasawa, Masahiro. . TRPV2. In Handbook of experimental pharmacology, 222, 247-72. doi:10.1007/978-3-642-54215-2_10. https://pubmed.ncbi.nlm.nih.gov/24756709/
2. Li, Cuifeng, Zhao, Meng, Liu, Xiaohang, Li, Zhanguo, Liu, Wanli. 2024. Ion channel TRPV2 is critical in enhancing B cell activation and function. In The Journal of experimental medicine, 221, . doi:10.1084/jem.20221042. https://pubmed.ncbi.nlm.nih.gov/38353705/
3. Iwata, Yuko, Ito, Shin, Wakabayashi, Shigeo, Kitakaze, Masafumi. 2019. TRPV2 channel as a possible drug target for the treatment of heart failure. In Laboratory investigation; a journal of technical methods and pathology, 100, 207-217. doi:10.1038/s41374-019-0349-z. https://pubmed.ncbi.nlm.nih.gov/31857697/
4. Iwata, Yuko, Matsumura, Tsuyoshi. 2019. Blockade of TRPV2 is a Novel Therapy for Cardiomyopathy in Muscular Dystrophy. In International journal of molecular sciences, 20, . doi:10.3390/ijms20163844. https://pubmed.ncbi.nlm.nih.gov/31394715/
5. Guo, Yu-Yao, Gao, Yue, Zhao, Yun-Lin, Lin, Dandan, Yao, Jing. 2024. Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21. In Cell reports, 43, 114095. doi:10.1016/j.celrep.2024.114095. https://pubmed.ncbi.nlm.nih.gov/38613787/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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