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C57BL/6JCya-Eif3lem1flox/Cya
Common Name:
Eif3l-flox
Product ID:
S-CKO-06639
Background:
C57BL/6JCya
Product Type
Age
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Basic Information
Strain Name
Eif3l-flox
Strain ID
CKOCMP-223691-Eif3l-B6J-VA
Gene Name
Eif3l
Product ID
S-CKO-06639
Gene Alias
0610011H21Rik; D15N1e; Eif3eip; Eif3ip; Eif3s6ip; HSP-66Y; PAF67
Background
C57BL/6JCya
NCBI ID
223691
Modification
Conditional knockout
Chromosome
15
Phenotype
MGI:2386251
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Eif3lem1flox/Cya mice (Catalog S-CKO-06639) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000040518
NCBI RefSeq
NM_145139
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Eif3l, the eukaryotic translation initiation factor 3, subunit L, is one of the subunits of the eIF3 complex. It plays a crucial role in the translation of mRNAs encoding growth-promoting proteins, enhancing translation rates and thus controlling cell proliferation. It may also be involved in the Flavivirus replication through interaction with the viral non-structural 5 protein [2,4].

In human prostate LNCaP cells, androgen treatment significantly increases the palmitoylation level of eIF3L. The regulation of its palmitoylation may offer new directions for prostate cancer therapy, and the increased level of androgen-induced eIF3L could potentially be used as a biomarker for early-stage prostate cancer diagnosis [1].

In Caenorhabditis elegans, loss-of-function mutations in the eif-3.L gene result in a 40% extension in lifespan and enhanced resistance to endoplasmic reticulum stress, suggesting a pivotal role for eIF3L in the regulation of cellular and organismal responses to stress and aging [3].

In conclusion, Eif3L is essential in regulating cell proliferation and translation. Studies using genetic models like Caenorhabditis elegans have revealed its role in lifespan extension and stress resistance. In the context of prostate cancer, it shows promise as a therapeutic target and diagnostic biomarker.

References:
1. Cui, Luwei, Liu, Ming, Lai, Shicong, Zhang, Yaoguang, Wang, Jianye. 2019. Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells. In OncoTargets and therapy, 12, 4451-4459. doi:10.2147/OTT.S193480. https://pubmed.ncbi.nlm.nih.gov/31239713/
2. Morais, Ana T S, Meza, Andreia N, Araújo, Gabriela C, Murakami, Mário T, Nogueira, Mauricio L. . Biophysical and structural characterization of the recombinant human eIF3L. In Protein and peptide letters, 21, 56-62. doi:. https://pubmed.ncbi.nlm.nih.gov/23919378/
3. Cattie, Douglas J, Richardson, Claire E, Reddy, Kirthi C, Gilbert, Wendy V, Kim, Dennis H. 2016. Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans. In PLoS genetics, 12, e1006326. doi:10.1371/journal.pgen.1006326. https://pubmed.ncbi.nlm.nih.gov/27690135/
4. Morais, Ana Ts, Terzian, Ana Cb, Duarte, Danilo Vb, Rahal, Paula, Nogueira, Mauricio L. 2013. The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication. In Virology journal, 10, 205. doi:10.1186/1743-422X-10-205. https://pubmed.ncbi.nlm.nih.gov/23800076/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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