C57BL/6JCya-Krt73em1flox/Cya
Common Name
Krt73-flox
Product ID
S-CKO-06679
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-223915-Krt73-B6J-VA
When using this mouse strain in a publication, please cite “Krt73-flox Mouse (Catalog S-CKO-06679) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Krt73-flox
Strain ID
CKOCMP-223915-Krt73-B6J-VA
Gene Name
Product ID
S-CKO-06679
Gene Alias
K73, Kb36, CK-73
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000063292
NCBI RefSeq
NM_212485
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Overview of Gene Research
Krt73, an inner root sheath-specific type II keratin gene, is crucial for hair follicle development and may be involved in multiple biological processes [3,4]. Inner root sheath keratins play important roles in maintaining the structure and function of hair follicles, and are likely to be associated with pathways related to hair growth and skin development. Genetic models, such as mouse models, can be valuable tools for studying the function of Krt73.
In a proteomic study of iRhom2(Uncv) mice with a hairless phenotype, Krt73 was among the differentially expressed proteins in the skin compared to wild-type littermates, suggesting its potential participation in the mechanism by which iRhom2 regulates murine skin development [1]. In another study on alopecia areata, a transcription factor EOMEs was found to potentially affect keratinocytes function via regulating Krt73 expression, indicating a role for Krt73 in the pathogenesis of alopecia areata [2].
In conclusion, Krt73 is essential for hair-related biological processes, as revealed through model-based research. Its differential expression in mouse models of skin-related phenotypes and in alopecia areata patients' lesions highlights its significance in understanding the mechanisms of hair-related diseases, potentially providing new insights for diagnosis and treatment.
References：
1. Liu, Bing, Xu, Yuan, Li, Wen-Long, Zeng, Lin. . Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice. In BMB reports, 48, 19-24. doi:. https://pubmed.ncbi.nlm.nih.gov/24667173/
2. Yuan, Xin, Tang, Yan, Zhao, Zhixiang, Zhang, Yiya, Li, Ji. 2020. Identification and verification of EOMEs regulated network in Alopecia areata. In International immunopharmacology, 84, 106544. doi:10.1016/j.intimp.2020.106544. https://pubmed.ncbi.nlm.nih.gov/32353685/
3. Shi, An, Lv, Jiangjiang, Ma, Qing, Zhou, Junsheng, Tao, Jinzhong. 2024. Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages. In Gene, 927, 148751. doi:10.1016/j.gene.2024.148751. https://pubmed.ncbi.nlm.nih.gov/38971547/
4. Langbein, Lutz, Rogers, Michael A, Praetzel, Silke, Winter, Hermelita, Schweizer, Jürgen. . K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. In The Journal of investigative dermatology, 120, 512-22. doi:. https://pubmed.ncbi.nlm.nih.gov/12648212/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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