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C57BL/6JCya-Dzip3em1flox/Cya
Common Name:
Dzip3-flox
Product ID:
S-CKO-06724
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Dzip3-flox
Strain ID
CKOCMP-224170-Dzip3-B6J-VA
Gene Name
Dzip3
Product ID
S-CKO-06724
Gene Alias
2310047C04Rik; 2A-HUB; 6430549P11Rik; A230104G20
Background
C57BL/6JCya
NCBI ID
224170
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:1917433
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dzip3em1flox/Cya mice (Catalog S-CKO-06724) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000121869
NCBI RefSeq
NM_001110017
Target Region
Exon 3~4
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Dzip3, also known as DAZ-interacting zinc finger 3, is an RNA-binding RING-type ubiquitin ligase. It is involved in multiple physiological functions, such as regulating chemokine-or estradiol-induced gene expression, self-renewal, and maintaining pluripotency in mouse embryonic stem cells. It also participates in epigenetic regulation, like histone H2A ubiquitination, and is associated with pathways related to cell-cycle regulation and cancer progression [4,5,6].

In glioma, lower DZIP3 expression is related to malignancy, and it serves as an independent predictive factor of good prognosis. Gene enrichment analysis indicated it affects glioma biological behavior through the angiogenesis pathway. In IDH1 wild-type lower-grade gliomas, DZIP3 expression can stratify patients into two groups with different survival times [1].

In gastric cancer, DZIP3 is significantly up-regulated, promoting cell proliferation and metastasis. Its higher expression is associated with poor prognosis. Proteomic and transcriptome analyses showed its interaction with epigenetic regulators and its impact on genes crucial for tumors [2].

In cancer cell models, DZIP3 promoted tumor growth and metastasis. Depletion of DZIP3 led to reduced Cyclin D1 expression, G1 arrest, and defective cell growth. DZIP3 stabilizes Cyclin D1 at both mRNA and protein levels in a cell-cycle phase-dependent manner [3].

In addition, the 1st exon DNA methylation of DZIP3 can predict the onset of early-stage and all pTNM stages of colorectal cancer [7].

In conclusion, Dzip3 is a key factor in multiple biological processes and disease conditions. Its functions in promoting cell-cycle progression, as well as its role in cancer development and progression, are well-demonstrated through various in vivo and in vitro studies. The research on Dzip3 provides valuable insights into the mechanisms of cancer and other diseases, offering potential targets for treatment.

References:
1. Liang, Tingyu, Zhou, Xingang, Li, Peiliang, Wang, Peng, Feng, Enshan. 2020. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas. In Aging, 12, 24995-25004. doi:10.18632/aging.103817. https://pubmed.ncbi.nlm.nih.gov/33229627/
2. Qiu, Rongfang, Zhao, Siyu, Lu, Chenying, Yang, Yang, Ji, Jiansong. 2023. Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells. In Experimental cell research, 425, 113525. doi:10.1016/j.yexcr.2023.113525. https://pubmed.ncbi.nlm.nih.gov/36841324/
3. Kolapalli, Srinivasa P, Sahu, Rinku, Chauhan, Nishant R, Chauhan, Santosh, Chauhan, Swati. 2020. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. In Cancer research, 81, 315-331. doi:10.1158/0008-5472.CAN-20-1871. https://pubmed.ncbi.nlm.nih.gov/33067265/
4. Purcell, Daniel J, Chauhan, Swati, Jimenez-Stinson, Diane, Marples, Brian, Lee, David Y. 2015. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. In Molecular endocrinology (Baltimore, Md.), 29, 1708-19. doi:10.1210/me.2015-1083. https://pubmed.ncbi.nlm.nih.gov/26505218/
5. Oikawa, Daisuke, Shiota, Masayuki, Tokunaga, Fuminori, Wanibuchi, Hideki. 2018. Generation of Rat Monoclonal Antibodies Specific for DZIP3. In Monoclonal antibodies in immunodiagnosis and immunotherapy, 37, 153-157. doi:10.1089/mab.2018.0005. https://pubmed.ncbi.nlm.nih.gov/29812999/
6. Inoue, Daishi, Aihara, Hitoshi, Sato, Tatsuharu, Nakagawa, Takeya, Ito, Takashi. 2015. Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation. In Scientific reports, 5, 16567. doi:10.1038/srep16567. https://pubmed.ncbi.nlm.nih.gov/26568260/
7. Quan, Yuan, Liang, Fengji, Wu, Deqing, Li, Yong, Xiong, Jianghui. 2020. Blood Cell DNA Methylation of Aging-Related Ubiquitination Gene DZIP3 Can Predict the Onset of Early Stage Colorectal Cancer. In Frontiers in oncology, 10, 544330. doi:10.3389/fonc.2020.544330. https://pubmed.ncbi.nlm.nih.gov/33330022/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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