C57BL/6JCya-Adgrg7em1flox/Cya
Common Name
Adgrg7-flox
Product ID
S-CKO-08189
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-239853-Adgrg7-B6J-VA
When using this mouse strain in a publication, please cite “Adgrg7-flox Mouse (Catalog S-CKO-08189) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Adgrg7-flox
Strain ID
CKOCMP-239853-Adgrg7-B6J-VA
Gene Name
Product ID
S-CKO-08189
Gene Alias
Gpr128, 9130020O16Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023437
NCBI RefSeq
NM_172825
Target Region
Exon 4
Size of Effective Region
~0.8 kb
Overview of Gene Research
Adgrg7, also known as GPR128, is an adhesion G protein-coupled receptor (aGPCR) belonging to the ADGRG subfamily. aGPCRs play important roles in various physiological processes such as neurodevelopment, immune defence, and cancer [1,2,4]. However, the physiological role and regulation of Adgrg7 are not yet fully elucidated [3].
In a study on SARS-CoV-2 infection, the mRNA levels of Adgrg7 were upregulated in SARS-CoV-2-infected lung adenocarcinoma Calu-3 cells, and downregulation of Adgrg7 led to a decrease in the amount of newly released SARS-CoV-2 into the culture media and a reduction in its infectivity, suggesting its potential role in the viral infection process [2]. In breast cancer, high expression of Adgrg7 was significantly correlated with poor overall survival, indicating its possible involvement in breast cancer development [5]. Also, in uterine corpus endometrial carcinoma (UCEC), the expression level of Adgrg7 was significantly elevated, and high levels of it were associated with shorter overall survival and lower relapse-free survival, showing its potential as a prognostic marker and immunotherapeutic target in UCEC [6].
In conclusion, Adgrg7, an adhesion G protein-coupled receptor, has potential significance in multiple biological processes, especially in viral infection and cancer-related diseases. Studies on Adgrg7 in different disease models help to understand its functions and potential as a therapeutic target, providing insights for future disease treatment and prevention strategies.
References：
1. Hamann, Jörg, Aust, Gabriela, Araç, Demet, Langenhan, Tobias, Schiöth, Helgi B. . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. In Pharmacological reviews, 67, 338-67. doi:10.1124/pr.114.009647. https://pubmed.ncbi.nlm.nih.gov/25713288/
2. Žáčková, Sandra, Pávová, Marcela, Trylčová, Jana, Lukšan, Ondřej, Weber, Jan. 2024. Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells. In Cells, 13, . doi:10.3390/cells13100791. https://pubmed.ncbi.nlm.nih.gov/38786015/
3. Hassan, Amani, Bagu, Edward T, Levesque, Mathieu, Tremblay, André, Moldovan, Florina. 2019. The 17β-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRα and SP1 complex. In Biology open, 8, . doi:10.1242/bio.037390. https://pubmed.ncbi.nlm.nih.gov/30598481/
4. Liessmann, Fabian, von Bredow, Lukas, Meiler, Jens, Liebscher, Ines. 2024. Targeting adhesion G protein-coupled receptors. Current status and future perspectives. In Structure (London, England : 1993), 32, 2188-2205. doi:10.1016/j.str.2024.10.022. https://pubmed.ncbi.nlm.nih.gov/39520987/
5. Shi, Wenning, Xu, Cong, Lei, Ping, Wang, Hongmei, Zhang, Dao-Lai. 2024. A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer. In Breast cancer research and treatment, 207, 417-434. doi:10.1007/s10549-024-07373-z. https://pubmed.ncbi.nlm.nih.gov/38834774/
6. Lei, Ping, Wang, Hongmei, Yu, Liting, Li, Lianqin, Zhang, Dao-Lai. 2022. A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer. In International immunopharmacology, 108, 108743. doi:10.1016/j.intimp.2022.108743. https://pubmed.ncbi.nlm.nih.gov/35413679/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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