C57BL/6JCya-Dock6em1flox/Cya
Common Name:
Dock6-flox
Product ID:
S-CKO-10356
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Dock6-flox
Strain ID
CKOCMP-319899-Dock6-B6J-VA
Gene Name
Product ID
S-CKO-10356
Gene Alias
2410095B20Rik; 4931431C02Rik; C330023D02Rik; mKIAA1395
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dock6em1flox/Cya mice (Catalog S-CKO-10356) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000217336
NCBI RefSeq
NM_177030
Target Region
Exon 6~7
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Dock6, a guanine nucleotide exchange factor (GEF) for Rac1 and CDC42, plays significant roles in multiple biological processes. It is involved in pathways such as the WNT/β -catenin signaling pathway, which is crucial for cell growth, differentiation, and development. Genetic models, like KO/CKO mouse models, are valuable for studying Dock6's functions and its implications in diseases [1].
In gastric cancer, Dock6 promotes chemo-and radioresistance by modulating WNT/β -catenin signaling and cancer stem cell traits. Its elevated expression is associated with poor prognosis [1]. In oral squamous cell cancer, Dock6 is upregulated, promoting cellular migration and invasion, also related to a poor prognosis [3]. In Adams-Oliver syndrome, autosomal recessive DOCK6-related forms often lead to severe phenotypes including central nervous system and ocular abnormalities, with intrafamilial phenotypic variability observed [2,4].
In conclusion, Dock6 is a key factor in cell-signaling pathways, influencing processes related to cancer progression and certain genetic syndromes. Studies using KO/CKO mouse models could potentially further clarify its functions and contribute to the understanding of related disease mechanisms, providing insights for possible therapeutic interventions in cancer and genetic disorder management.
References:
1. Chi, Hsiang-Cheng, Tsai, Chung-Ying, Wang, Chia-Siu, Chen, Wei-Jan, Lin, Kwang-Huei. 2020. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. In Oncogene, 39, 5933-5949. doi:10.1038/s41388-020-01390-0. https://pubmed.ncbi.nlm.nih.gov/32753649/
2. Zepeda-Romero, Luz Consuelo, Zenker, Martin, Schanze, Denny, Corona-Rivera, Alfredo, Corona-Rivera, Jorge Román. 2022. Intrafamilial phenotypic variability in autosomal recessive DOCK6-related Adams-Oliver syndrome. In European journal of medical genetics, 65, 104653. doi:10.1016/j.ejmg.2022.104653. https://pubmed.ncbi.nlm.nih.gov/36330903/
3. Zhang, Ze-Ying, Sun, Yuan-Yuan, Wang, He-Chen, Fu, Wei-Neng, Sun, Chang-Fu. 2021. Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis. In Archives of oral biology, 133, 105297. doi:10.1016/j.archoralbio.2021.105297. https://pubmed.ncbi.nlm.nih.gov/34742001/
4. Sukalo, Maja, Tilsen, Felix, Kayserili, Hülya, Southgate, Laura, Zenker, Martin. 2015. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies. In Human mutation, 36, 593-8. doi:10.1002/humu.22795. https://pubmed.ncbi.nlm.nih.gov/25824905/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen