Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Elaneem1flox/Cya
Common Name:
Elane-flox
Product ID:
S-CKO-11367
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Elane-flox
Strain ID
CKOCMP-50701-Elane-B6N-VA
Gene Name
Elane
Product ID
S-CKO-11367
Gene Alias
Ela2; F430011M15Rik; NE
Background
C57BL/6NCya
NCBI ID
50701
Modification
Conditional knockout
Chromosome
10
Phenotype
MGI:2679229
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Elaneem1flox/Cya mice (Catalog S-CKO-11367) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000046091
NCBI RefSeq
NM_015779
Target Region
Exon 1~3
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Elane, encoding neutrophil elastase, is closely associated with neutrophil maturation and functions [2,4,5,6,8]. Neutrophil elastase is involved in leukocyte transmigration to infection sites and clearance of Gram-negative bacteria, but also activates inflammation in chronic airway diseases [7]. It is crucial in innate immune responses and has been linked to multiple disease-related pathways.

Mutations in Elane cause cyclic neutropenia (CyN) and severe congenital neutropenia (SCN), with diverse mutations observed in patients [4]. These mutations can lead to impaired neutrophil differentiation, and patients may be at risk of developing myelodysplasia or acute myeloid leukemia [2,4,5,8]. In gastric cancer, Elane is significantly up-regulated, affecting patient survival and involved in pyroptosis and immune infiltration, potentially serving as a prognostic biomarker [1]. Human neutrophils release catalytically active Elane to selectively kill cancer cells, suggesting its potential as an anti-cancer therapy [3].

In conclusion, Elane is essential for neutrophil-related functions and innate immunity. Research on Elane-associated neutropenia and its role in cancer, through genetic models and patient studies, has provided insights into disease mechanisms. Understanding Elane's functions can offer new perspectives for treating neutropenia, leukemia, and gastric cancer.

References:
1. Cui, Ming, Wang, Xiaowu, Qiao, Haiyan, Wu, Shixi, Shang, Bingbing. 2024. ELANE is a promising prognostic biomarker that mediates pyroptosis in gastric cancer. In Heliyon, 10, e34360. doi:10.1016/j.heliyon.2024.e34360. https://pubmed.ncbi.nlm.nih.gov/39130462/
2. Nasri, Masoud, Ritter, Malte U, Mir, Perihan, Welte, Karl, Skokowa, Julia. 2024. CRISPR-Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia. In Molecular therapy : the journal of the American Society of Gene Therapy, 32, 1628-1642. doi:10.1016/j.ymthe.2024.03.037. https://pubmed.ncbi.nlm.nih.gov/38556793/
3. Cui, Chang, Chakraborty, Kasturi, Tang, Xu Anna, Greene, Geoffrey, Becker, Lev. 2021. Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis. In Cell, 184, 3163-3177.e21. doi:10.1016/j.cell.2021.04.016. https://pubmed.ncbi.nlm.nih.gov/33964209/
4. Makaryan, Vahagn, Zeidler, Cornelia, Bolyard, Audrey Anna, Welte, Karl, Dale, David C. . The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. In Current opinion in hematology, 22, 3-11. doi:10.1097/MOH.0000000000000105. https://pubmed.ncbi.nlm.nih.gov/25427142/
5. Skokowa, Julia, Dale, David C, Touw, Ivo P, Zeidler, Cornelia, Welte, Karl. 2017. Severe congenital neutropenias. In Nature reviews. Disease primers, 3, 17032. doi:10.1038/nrdp.2017.32. https://pubmed.ncbi.nlm.nih.gov/28593997/
6. Rao, Shuquan, Yao, Yao, Soares de Brito, Josias, Newburger, Peter E, Bauer, Daniel E. 2021. Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. In Cell stem cell, 28, 833-845.e5. doi:10.1016/j.stem.2020.12.015. https://pubmed.ncbi.nlm.nih.gov/33513358/
7. Voynow, Judith A, Shinbashi, Meagan. 2021. Neutrophil Elastase and Chronic Lung Disease. In Biomolecules, 11, . doi:10.3390/biom11081065. https://pubmed.ncbi.nlm.nih.gov/34439732/
8. Wang, Jing, Zhang, Haitao, Wang, Yu, Liang, Lei, Yang, Zeyu. . Severe congenital neutropenia caused by ELANE gene mutation: A case report and literature review. In Medicine, 101, e31357. doi:10.1097/MD.0000000000031357. https://pubmed.ncbi.nlm.nih.gov/36343040/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest