C57BL/6JCya-Atxn1lem1flox/Cya
Common Name
Atxn1l-flox
Product ID
S-CKO-11497
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-52335-Atxn1l-B6J-VA
When using this mouse strain in a publication, please cite “Atxn1l-flox Mouse (Catalog S-CKO-11497) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Atxn1l-flox
Strain ID
CKOCMP-52335-Atxn1l-B6J-VA
Gene Name
Product ID
S-CKO-11497
Gene Alias
Boat, C330011L24Rik, D6Mgi37, D8Ertd587e
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000093162
NCBI RefSeq
NM_001080930
Target Region
Exon 4
Size of Effective Region
~2.4 kb
Overview of Gene Research
Atxn1l, also known as ataxin 1-like, is a protein-coding gene. It is involved in multiple biological processes. It interacts with CIC (capicua) to form a transcription repressor complex, and this complex plays a role in modulating the sensitivity to MAPK pathway inhibition [1,3,4]. It is also related to the Notch-driven marginal zone B cell development and sepsis progression [2].
In loss-of-function studies, ATXN1L deletion reduces CIC protein, which in turn modulates sensitivity to the MEK1/2 inhibitor trametinib in cancer cells [1]. In B cell-specific Atxn1l-deficient (Atxn1lf/f;Cd19-Cre) mice, Notch signaling is disrupted in marginal zone B cells, leading to inhibited MZB cell development due to ETV4 de-repression and subsequent inhibition of Notch1 and Notch2 transcription. Also, in these mice, humoral immune responses and lipopolysaccharide-induced sepsis progression are attenuated but restored upon Etv4-deletion [2].
In conclusion, Atxn1l is essential for the regulation of multiple biological processes, especially through its interaction with CIC. The Atxn1l-deficient mouse models have revealed its significance in cancer drug sensitivity, B cell development, and sepsis progression, providing valuable insights into the underlying mechanisms of these biological processes and disease conditions.
References：
1. Wang, Belinda, Krall, Elsa Beyer, Aguirre, Andrew James, Root, David Edward, Hahn, William Chun. . ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. In Cell reports, 18, 1543-1557. doi:10.1016/j.celrep.2017.01.031. https://pubmed.ncbi.nlm.nih.gov/28178529/
2. Park, Jong Seok, Kang, Minjung, Kim, Han Bit, Kim, Tae-Kyung, Lee, Yoontae. 2024. The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression. In Nature communications, 15, 10579. doi:10.1038/s41467-024-54803-z. https://pubmed.ncbi.nlm.nih.gov/39632849/
3. Wong, Derek, Lounsbury, Kohl, Lum, Amy, Marra, Marco, Yip, Stephen. 2018. Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer. In Oncogene, 38, 273-290. doi:10.1038/s41388-018-0427-5. https://pubmed.ncbi.nlm.nih.gov/30093628/
4. Wong, Derek, Sogerer, Lisa, Lee, Samantha S, Marra, Marco A, Yip, Stephen. 2020. TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L. In BMC biology, 18, 154. doi:10.1186/s12915-020-00895-0. https://pubmed.ncbi.nlm.nih.gov/33115448/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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