C57BL/6JCya-Rbm14em1flox/Cya
Common Name:
Rbm14-flox
Product ID:
S-CKO-12002
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Rbm14-flox
Strain ID
CKOCMP-56275-Rbm14-B6J-VA
Gene Name
Product ID
S-CKO-12002
Gene Alias
1300007E16Rik; PSP2; Sytip; p16; p16K
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rbm14em1flox/Cya mice (Catalog S-CKO-12002) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000006625
NCBI RefSeq
NM_019869
Target Region
Exon 2
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
Rbm14, an RNA-binding protein, is involved in multiple essential biological processes. It plays a role in maintaining genome integrity, regulating alternative splicing, and is associated with pathways like homologous recombination repair, DNA damage response, and cellular O-GlcNAcylation. It also has significance in embryonic development, oocyte maturation, and cancer-related processes [1,3,4,6].
In gene knockout studies, Rbm14 knockout in mice leads to apoptosis and cell proliferation defects in early post-implantation epiblast cells, causing gastrulation disruption and embryonic lethality. This indicates its crucial role in maintaining genome integrity during early mouse embryogenesis by regulating alternative splicing of DNA damage response (DDR)-related genes [4]. Rbm14 depletion in mouse embryonic stem cells (mESCs) alters gene expression profiles, downregulating pluripotency-associated genes and genes in the Wnt and TGF-β signaling pathways, showing its importance in maintaining pluripotency and mesoderm development [6]. In mouse oocytes, Rbm14 knockdown results in spindle defects and chromosome abnormalities due to α-tubulin hyperacetylation, highlighting its role in oocyte meiotic maturation [3].
In conclusion, Rbm14 is essential for multiple biological functions including genome integrity maintenance, pluripotency, and oocyte maturation. Studies using gene knockout mouse models have revealed its significance in early embryonic development and provided insights into its potential as a therapeutic target in diseases such as cancer where its dysregulation is observed [2,4,5].
References:
1. Li, Zheng, Liao, Yanting, Tang, Chen, Peng, Bin, Xu, Xingzhi. . RBM14 promotes DNA end resection during homologous recombination repair. In Acta biochimica et biophysica Sinica, 55, 1864-1873. doi:10.3724/abbs.2023104. https://pubmed.ncbi.nlm.nih.gov/37559455/
2. Hu, Yan, Mu, Hanshuo, Deng, Zhiping. 2023. RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer. In World journal of surgical oncology, 21, 132. doi:10.1186/s12957-023-02928-8. https://pubmed.ncbi.nlm.nih.gov/37060064/
3. Qin, Hao, Qu, Yi, Yuan, Yi-Feng, Li, Yang-Yang, Qiao, Jie. 2021. RBM14 Modulates Tubulin Acetylation and Regulates Spindle Morphology During Meiotic Maturation in Mouse Oocytes. In Frontiers in cell and developmental biology, 9, 635728. doi:10.3389/fcell.2021.635728. https://pubmed.ncbi.nlm.nih.gov/33604343/
4. Li, Jing, Wang, Chenxin, Feng, Guihai, Zhou, Qi, Li, Wei. 2019. Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. In Cell proliferation, 53, e12724. doi:10.1111/cpr.12724. https://pubmed.ncbi.nlm.nih.gov/31794640/
5. Lin, Sijian, Xiong, Jiachao, Zhou, Faxin, Luo, Jun, Cao, Kai. 2024. Molecular mechanism of RBM14-mediated promotion of proliferation, migration, and invasion in osteosarcoma. In Translational cancer research, 13, 2122-2140. doi:10.21037/tcr-23-2070. https://pubmed.ncbi.nlm.nih.gov/38881928/
6. Chen, Guilai, Zhang, Da, Zhang, Linlin, Zhang, Ying, Hu, Baoyang. 2018. RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. In Biochemical and biophysical research communications, 501, 259-265. doi:10.1016/j.bbrc.2018.04.231. https://pubmed.ncbi.nlm.nih.gov/29729270/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen