C57BL/6JCya-Stk32cem1flox/Cya
Common Name
Stk32c-flox
Product ID
S-CKO-12342
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-57740-Stk32c-B6J-VA
When using this mouse strain in a publication, please cite “Stk32c-flox Mouse (Catalog S-CKO-12342) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Stk32c-flox
Strain ID
CKOCMP-57740-Stk32c-B6J-VA
Gene Name
Product ID
S-CKO-12342
Gene Alias
PKE, Pkek, YANK3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000016125
NCBI RefSeq
NM_021302
Target Region
Exon 3~4
Size of Effective Region
~3.5 kb
Overview of Gene Research
STK32C, a member of the serine/threonine protein kinase of AGC superfamily, was first found highly expressed in brain tissues. Its biological function was once unknown, but recent research has associated it with multiple important biological processes. It may be involved in kinase-related pathways and could potentially play a role in regulating various cellular functions [3,2].
In triple-negative breast cancer (TNBC), STK32C depletion significantly augmented the sensitivity of doxorubicin-resistant TNBC cells to doxorubicin, with the cytoplasmic subset of STK32C mediating this effect mainly through glycolysis regulation [1]. In bladder cancer, slicing of STK32C inhibited tumor cell proliferation, migration and invasion in vitro, and knocking-down of STK32C restricted the growth of tumor cells in mice in vivo, while also inhibiting the activity of the HMGB1 pathway [2].
In conclusion, STK32C is a kinase that appears to play a role in cancer-related processes, particularly in modulating drug resistance in TNBC and promoting tumor progression in bladder cancer. Understanding the function of STK32C through in vivo studies like those in mouse models can potentially provide new therapeutic targets for these cancers.
References：
1. Xiao, Huawei, Liu, Lei, Huang, Shaoyan. 2024. STK32C modulates doxorubicin resistance in triple-negative breast cancer cells via glycolysis regulation. In Molecular and cellular biochemistry, 480, 459-471. doi:10.1007/s11010-024-04989-z. https://pubmed.ncbi.nlm.nih.gov/38507019/
2. Sun, Erlin, Liu, Kangkang, Zhao, Kun, Wang, Lining. 2018. Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression. In Cancer biology & therapy, 20, 307-320. doi:10.1080/15384047.2018.1529098. https://pubmed.ncbi.nlm.nih.gov/30359551/
3. Dempster, Emma L, Wong, Chloe C Y, Lester, Kathryn J, Mill, Jonathan, Eley, Thalia C. 2014. Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. In Biological psychiatry, 76, 977-83. doi:10.1016/j.biopsych.2014.04.013. https://pubmed.ncbi.nlm.nih.gov/24929637/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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