C57BL/6JCya-Ace2em1flox/Cya
Common Name
Ace2-flox
Product ID
S-CKO-14709
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-70008-Ace2-B6J-VA
When using this mouse strain in a publication, please cite “Ace2-flox Mouse (Catalog S-CKO-14709) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ace2-flox
Strain ID
CKOCMP-70008-Ace2-B6J-VA
Gene Name
Product ID
S-CKO-14709
Gene Alias
2010305L05Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000112271
NCBI RefSeq
NM_001130513
Target Region
Exon 4~5
Size of Effective Region
~2.8 kb
Overview of Gene Research
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is a key part of the renin-angiotensin system (RAS) [1,2,5,6,9]. It maintains homeostasis by inhibiting the Ang II-AT1R axis and activating the Ang I (1-7)-MasR axis, protecting against lung, heart and kidney injury [1]. ACE2 also helps transport amino acids across the membrane [1]. Additionally, it is involved in regulating glycolipid metabolism in multiple tissues, such as the lungs, cardiovascular system, gastrointestinal tract, kidney, pancreas and adipose tissue [5].
In the context of COVID-19, ACE2 is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) [1,2,3,4,6,7,8,10]. SARS-COV-2 binding to ACE2 may lead to down-regulation of the membrane-bound enzyme, causing functional ACE2 deficiency, angiotensin imbalance, immune dysregulation and endothelial cell dysfunction [6]. Also, ACE2 levels are regulated by transcriptional, post-transcriptional, and post-translational regulation or modification [2]. Polymorphisms of ACE2 are associated with various diseases, including the severity of SARS-COV-2 infection [10].
In conclusion, ACE2 is essential for maintaining homeostasis, regulating metabolism and is a crucial factor in the pathophysiology of COVID-19. Understanding its functions and regulations through genetic models can provide insights into developing strategies for treating related diseases.
References：
1. Wang, Jieqiong, Zhao, Huiying, An, Youzhong. 2022. ACE2 Shedding and the Role in COVID-19. In Frontiers in cellular and infection microbiology, 11, 789180. doi:10.3389/fcimb.2021.789180. https://pubmed.ncbi.nlm.nih.gov/35096642/
2. Wang, Chia-Wen, Chuang, Huai-Chia, Tan, Tse-Hua. 2023. ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification. In Journal of biomedical science, 30, 71. doi:10.1186/s12929-023-00965-9. https://pubmed.ncbi.nlm.nih.gov/37608279/
3. Samtani, Ratika, Krishna, Kabir. . ACE2 and COVID-19: An anthropological perspective. In Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur, 78, 253-256. doi:10.1127/anthranz/2021/1327. https://pubmed.ncbi.nlm.nih.gov/33595589/
4. Snyder, Eric M, Johnson, Bruce D. 2020. ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations. In Pharmacogenomics, 21, 695-703. doi:10.2217/pgs-2020-0048. https://pubmed.ncbi.nlm.nih.gov/32501190/
5. Li, Rui, Li, Fangyu, Yuan, Li. . ACE2 Regulates Glycolipid Metabolism in Multiple Tissues. In Frontiers in bioscience (Landmark edition), 29, 17. doi:10.31083/j.fbl2901017. https://pubmed.ncbi.nlm.nih.gov/38287822/
6. Cook, Joshua R, Ausiello, John. 2021. Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19. In Reviews in endocrine & metabolic disorders, 23, 151-170. doi:10.1007/s11154-021-09663-z. https://pubmed.ncbi.nlm.nih.gov/34195965/
7. Jia, Hongpeng, Neptune, Enid, Cui, Honggang. . Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges. In American journal of respiratory cell and molecular biology, 64, 416-425. doi:10.1165/rcmb.2020-0322PS. https://pubmed.ncbi.nlm.nih.gov/33296619/
8. Memon, Bushra, Abdelalim, Essam M. 2021. ACE2 function in the pancreatic islet: Implications for relationship between SARS-CoV-2 and diabetes. In Acta physiologica (Oxford, England), 233, e13733. doi:10.1111/apha.13733. https://pubmed.ncbi.nlm.nih.gov/34561952/
9. Beacon, Tasnim H, Delcuve, Geneviève P, Davie, James R. 2020. Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1. In Genome, 64, 386-399. doi:10.1139/gen-2020-0124. https://pubmed.ncbi.nlm.nih.gov/33086021/
10. Singh, HariOm, Choudhari, Ranjana, Nema, Vijay, Khan, Abdul Arif. 2020. ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease. In Microbial pathogenesis, 150, 104621. doi:10.1016/j.micpath.2020.104621. https://pubmed.ncbi.nlm.nih.gov/33278516/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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