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C57BL/6JCya-Cmipem1flox/Cya
Common Name:
Cmip-flox
Product ID:
S-CKO-16007
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Cmip-flox
Strain ID
CKOCMP-74440-Cmip-B6J-VA
Gene Name
Cmip
Product ID
S-CKO-16007
Gene Alias
4933407C03Rik; 5830471E12Rik
Background
C57BL/6JCya
NCBI ID
74440
Modification
Conditional knockout
Chromosome
8
Phenotype
MGI:1921690
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cmipem1flox/Cya mice (Catalog S-CKO-16007) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000166750
NCBI RefSeq
NM_001163262
Target Region
Exon 8
Size of Effective Region
~1.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cmip, also known as C-Maf-inducing protein, is involved in multiple biological processes and disease-related pathways. In T cells, it acts as a negative regulator of signaling, influencing proximal signaling and cytoskeletal rearrangement [1]. In podocytes, it can interact with WT1 and target it for proteasome degradation, potentially playing a role in podocyte-related diseases [2]. It is also associated with Herceptin resistance in HER2-positive gastric cancer cells [3], and the development of non-alcoholic fatty liver disease (NAFLD) through the regulation of the Gbp2-Pparγ-CD36 axis [4].

In the context of disease, CMIP SNPs and their haplotypes are linked to dyslipidemia and clinicopathologic features of IgA nephropathy [5]. In glioma and gastric cancer, CMIP promotes cell proliferation, metastasis, and is considered oncogenic [6,7]. In the study of free fatty acid biology, CMIP protects cells from FFA exposure by modulating Akt signaling [8]. Moreover, CMIP haploinsufficiency may be the cause of syndromic autism spectrum disorder in some patients [9], and WT1 represses CMIP transcription in podocytes [10].

In conclusion, Cmip is a multifunctional protein involved in various biological processes and disease conditions. Studies, especially those using genetic models such as gene knockout or conditional knockout mouse models, have revealed its roles in T-cell regulation, podocyte function, cancer development, lipid-related diseases, and neurological disorders. Understanding Cmip's functions provides potential therapeutic targets for these diseases.

References:
1. Oniszczuk, Julie, Sendeyo, Kelhia, Chhuon, Cerina, Sahali, Dil, Ollero, Mario. 2019. CMIP is a negative regulator of T cell signaling. In Cellular & molecular immunology, 17, 1026-1041. doi:10.1038/s41423-019-0266-5. https://pubmed.ncbi.nlm.nih.gov/31395948/
2. Zhang, Shao-Yu, Fan, Qingfeng, Moktefi, Anissa, Sahali, Dil, Henique, Carole. . CMIP interacts with WT1 and targets it on the proteasome degradation pathway. In Clinical and translational medicine, 11, e460. doi:10.1002/ctm2.460. https://pubmed.ncbi.nlm.nih.gov/34323419/
3. Xiang, Ru, Han, Xiaowen, Ding, Keshuo, Wu, Zhengsheng. 2019. CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells. In Pathology, research and practice, 216, 152776. doi:10.1016/j.prp.2019.152776. https://pubmed.ncbi.nlm.nih.gov/31822364/
4. Lee, Jangho, Song, Ji-Hye, Park, Jae-Ho, Hwang, Jin-Taek, Choi, Hyo-Kyoung. 2023. Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis. In Experimental & molecular medicine, 55, 143-157. doi:10.1038/s12276-022-00919-5. https://pubmed.ncbi.nlm.nih.gov/36609599/
5. Pan, Ling, Liao, Yun-Hua, Mo, Man-Qiu, Zhang, Qing-Hui, Yin, Rui-Xing. . CMIP SNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy. In Bioscience reports, 40, . doi:10.1042/BSR20202628. https://pubmed.ncbi.nlm.nih.gov/33112407/
6. Wang, Bin, Wu, Zheng-Sheng, Wu, Qiang. 2017. CMIP Promotes Proliferation and Metastasis in Human Glioma. In BioMed research international, 2017, 5340160. doi:10.1155/2017/5340160. https://pubmed.ncbi.nlm.nih.gov/28744466/
7. Zhang, Jianlin, Huang, Jin, Wang, Xingyu, Fang, Maoyong, Qian, Yeben. 2017. CMIP is oncogenic in human gastric cancer cells. In Molecular medicine reports, 16, 7277-7286. doi:10.3892/mmr.2017.7541. https://pubmed.ncbi.nlm.nih.gov/28944848/
8. Wieder, Nicolas, Fried, Juliana Coraor, Kim, Choah, Pablo, Juan Lorenzo, Greka, Anna. 2023. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. In Cell metabolism, 35, 887-905.e11. doi:10.1016/j.cmet.2023.03.018. https://pubmed.ncbi.nlm.nih.gov/37075753/
9. Luo, Minjie, Fan, Jinbo, Wenger, Tara L, Spinner, Nancy B, Conlin, Laura K. 2017. CMIP haploinsufficiency in two patients with autism spectrum disorder and co-occurring gastrointestinal issues. In American journal of medical genetics. Part A, 173, 2101-2107. doi:10.1002/ajmg.a.38277. https://pubmed.ncbi.nlm.nih.gov/28504353/
10. Moktefi, Anissa, Zhang, Shao-Yu, Vachin, Pauline, Sahali, Djillali, Pawlak, Andre. 2016. Repression of CMIP transcription by WT1 is relevant to podocyte health. In Kidney international, 90, 1298-1311. doi:10.1016/j.kint.2016.07.016. https://pubmed.ncbi.nlm.nih.gov/27650733/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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