C57BL/6JCya-Fam167bem1flox/Cya
Common Name:
Fam167b-flox
Product ID:
S-CKO-17932
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fam167b-flox
Strain ID
CKOCMP-230766-Fam167b-B6J-VB
Gene Name
Product ID
S-CKO-17932
Gene Alias
SEC
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam167bem1flox/Cya mice (Catalog S-CKO-17932) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000052835
NCBI RefSeq
NM_182783
Target Region
Exon 1~2
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Fam167b, along with Fam167A, belongs to the FAM167 gene family. These genes are evolutionarily conserved and not homologous to other annotated genes. The proteins they encode, DIORA-1 (from Fam167A) and DIORA-2 (presumably from Fam167b), are characterized by a high content of intrinsic disorder [1].
The reference focuses more on Fam167A in rheumatic diseases. It found that autoimmune risk genotypes within the FAM167A-BLK locus lead to increased expression of Fam167A. DIORA-1 has high expression in the lung, specifically in bronchial epithelium and alveolar macrophages with an endosomal localization pattern, suggesting a potential role in rheumatic disease pathogenesis [1].
In summary, while the reference mainly explored Fam167A, the FAM167 gene family including Fam167b shows conserved features and the encoded proteins' disordered nature might be relevant. The study of Fam167b in relation to rheumatic diseases could potentially provide more insights into disease mechanisms, similar to how the exploration of Fam167A has pointed to its role in the pathogenesis of rheumatic diseases [1].
References：
1. Mentlein, L, Thorlacius, G E, Meneghel, L, Espinosa, A, Wahren-Herlenius, M. 2018. The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages. In Clinical and experimental immunology, 193, 167-177. doi:10.1111/cei.13138. https://pubmed.ncbi.nlm.nih.gov/29663334/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen