C57BL/6JCya-Pomcem1flox/Cya
Common Name
Pomc-flox
Product ID
S-CKO-17973
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18976-Pomc-B6J-VB
When using this mouse strain in a publication, please cite “Pomc-flox Mouse (Catalog S-CKO-17973) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pomc-flox
Strain ID
CKOCMP-18976-Pomc-B6J-VB
Gene Name
Product ID
S-CKO-17973
Gene Alias
ACTH, BE, Beta-LPH, Clip, Gamma-LPH, Npp, Pomc-1, Pomc1, alpha-MSH, alphaMSH, beta-MSH, gamma-MSH
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 12
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020990
NCBI RefSeq
NM_008895
Target Region
Exon 2~3
Size of Effective Region
~2.7 kb
Overview of Gene Research
Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and neuropeptides. It plays a crucial role in integrating a range of vital physiological functions, such as maintaining the hypothalamic-pituitary-adrenal axis in the pituitary, and regulating appetite, energy homeostasis, and body composition in hypothalamic neurons [1]. POMC is also involved in the central melanocortin system, a pathway regulating energy metabolism [2].
Deleting TLR4 in POMC neurons of male mice increases energy expenditure and thermogenesis, reducing body weight, while in female mice, it decreases energy expenditure and increases body weight, affecting white adipose tissue lipolysis [3]. POMC-Cre-mediated Marchf6-deficient mice exhibit hyperphagia, reduced energy expenditure, and weight gain, suggesting Marchf6 is a critical regulator in POMC neurons [4].
In conclusion, POMC is essential for multiple physiological functions including energy metabolism and thermogenesis. Studies using gene-knockout mouse models, like those targeting TLR4 and Marchf6 in POMC neurons, have provided insights into POMC-related metabolic diseases such as obesity, highlighting the importance of POMC in maintaining metabolic homeostasis.
References：
1. Harno, Erika, Gali Ramamoorthy, Thanuja, Coll, Anthony P, White, Anne. . POMC: The Physiological Power of Hormone Processing. In Physiological reviews, 98, 2381-2430. doi:10.1152/physrev.00024.2017. https://pubmed.ncbi.nlm.nih.gov/30156493/
2. Zhan, Cheng. . POMC Neurons: Feeding, Energy Metabolism, and Beyond. In Advances in experimental medicine and biology, 1090, 17-29. doi:10.1007/978-981-13-1286-1_2. https://pubmed.ncbi.nlm.nih.gov/30390283/
3. Li, Yongxiang, Zhu, Shuqing, Du, Dan, Jiang, Qingyan, Wang, Lina. 2023. TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner. In Journal of lipid research, 64, 100368. doi:10.1016/j.jlr.2023.100368. https://pubmed.ncbi.nlm.nih.gov/37028769/
4. Mun, Sang-Hyeon, Lee, Chang-Seok, Kim, Hyun Jin, Seong, Je Kyung, Hwang, Cheol-Sang. 2023. Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons. In Cell reports, 42, 112746. doi:10.1016/j.celrep.2023.112746. https://pubmed.ncbi.nlm.nih.gov/37421621/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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