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C57BL/6JCya-Vipr1em1flox/Cya
Common Name:
Vipr1-flox
Product ID:
S-CKO-17991
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Vipr1-flox
Strain ID
CKOCMP-22354-Vipr1-B6J-VB
Gene Name
Vipr1
Product ID
S-CKO-17991
Gene Alias
VIP-R1; VPAC1
Background
C57BL/6JCya
NCBI ID
22354
Modification
Conditional knockout
Chromosome
9
Phenotype
MGI:109272
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vipr1em1flox/Cya mice (Catalog S-CKO-17991) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000035115
NCBI RefSeq
NM_011703.4
Target Region
Exon 4~6
Size of Effective Region
~2.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Vipr1, also known as the vasoactive intestinal peptide type-I receptor, is a G protein-associated receptor. It is involved in various biological processes. VIP, which binds to Vipr1, is released during immunologic and inflammatory responses, and Vipr1 is present on immune cells like mast cells, macrophages, B cells, and T cells, playing a role in immunomodulation [8]. It also has a part in maintaining gut microbiota homeostasis, as enteric neurons expressing VIP activate fut2 expression via the Erk1/2-c-Fos pathway through Vipr1 on intestinal epithelial cells, regulating α1,2-fucosylation [4].

In cancer research, Vipr1 shows potential tumor-suppressing roles. In lung adenocarcinoma, its overexpression significantly inhibits the growth, migration, and invasion of H1299 cells [1]. In hepatocellular carcinoma (HCC), the expression of Vipr1 is downregulated, and its activation suppresses HCC progression by regulating arginine and pyrimidine metabolism [2]. Also, the lncRNA-AC079061.1/Vipr1 axis may suppress HCC development [3]. Machine-learning-based analysis identified Vipr1 as a diagnostic biomarker for HCC, and its expression is positively correlated with several immune cells [5]. Epigenetic modifications, such as promoter methylation and H3K27 deacetylation, regulate Vipr1 transcription in HCC, and its overexpression causes cell cycle arrest, promotes apoptosis, and inhibits cell proliferation and tumor growth in HCC [6,7].

In conclusion, Vipr1 has diverse essential functions in immunomodulation and maintaining gut microbiota homeostasis. In cancer, especially in lung adenocarcinoma and HCC, Vipr1 appears to act as a tumor suppressor. Research on Vipr1, including through gene-knockout models (although not specifically detailed in the provided references), helps understand its role in disease mechanisms, potentially providing new strategies for cancer diagnosis and treatment.

References:
1. Zhao, Lufeng, Yu, Zipu, Zhao, Baiqin. 2019. Mechanism of VIPR1 gene regulating human lung adenocarcinoma H1299 cells. In Medical oncology (Northwood, London, England), 36, 91. doi:10.1007/s12032-019-1312-y. https://pubmed.ncbi.nlm.nih.gov/31560089/
2. Fu, Yaojie, Liu, Shanshan, Rodrigues, Robim M, Zeng, Shan, Shen, Hong. 2022. Activation of VIPR1 suppresses hepatocellular carcinoma progression by regulating arginine and pyrimidine metabolism. In International journal of biological sciences, 18, 4341-4356. doi:10.7150/ijbs.71134. https://pubmed.ncbi.nlm.nih.gov/35864952/
3. Lin, Xia-Hui, Zhang, Dan-Ying, Liu, Zhi-Yong, Weng, Shuqiang, Dong, Ling. 2022. lncRNA-AC079061.1/VIPR1 axis may suppress the development of hepatocellular carcinoma: a bioinformatics analysis and experimental validation. In Journal of translational medicine, 20, 379. doi:10.1186/s12967-022-03573-7. https://pubmed.ncbi.nlm.nih.gov/36038907/
4. Lei, Chao, Sun, Rui, Xu, Guangzhong, McClain, Craig J, Deng, Zhongbin. 2022. Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation. In Cell host & microbe, 30, 1417-1434.e8. doi:10.1016/j.chom.2022.09.001. https://pubmed.ncbi.nlm.nih.gov/36150396/
5. Ge, Song, Xu, Chen-Rui, Li, Yan-Ming, Ding, Liang, Niu, Jian. 2022. Identification of the Diagnostic Biomarker VIPR1 in Hepatocellular Carcinoma Based on Machine Learning Algorithm. In Journal of oncology, 2022, 2469592. doi:10.1155/2022/2469592. https://pubmed.ncbi.nlm.nih.gov/36157238/
6. Ning, S, He, C, Guo, Z, Zhang, H, Mo, Z. . [VIPR1 promoter methylation promotes transcription factor AP-2α binding to inhibit VIPR1 expression and promote hepatocellular carcinoma cell growth in vitro]. In Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 42, 957-965. doi:10.12122/j.issn.1673-4254.2022.07.01. https://pubmed.ncbi.nlm.nih.gov/35869757/
7. Lu, Sicong, Lu, Haiming, Jin, Rongzhong, Mo, Zhijing. 2018. Promoter methylation and H3K27 deacetylation regulate the transcription of VIPR1 in hepatocellular carcinoma. In Biochemical and biophysical research communications, 509, 301-305. doi:10.1016/j.bbrc.2018.12.129. https://pubmed.ncbi.nlm.nih.gov/30583864/
8. Goetzl, E J, Pankhaniya, R R, Gaufo, G O, Xia, M, Sreedharan, S P. . Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses. In Annals of the New York Academy of Sciences, 840, 540-50. doi:. https://pubmed.ncbi.nlm.nih.gov/9629281/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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