C57BL/6JCya-Rsrc1em1flox/Cya
Common Name:
Rsrc1-flox
Product ID:
S-CKO-18068
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rsrc1-flox
Strain ID
CKOCMP-66880-Rsrc1-B6J-VB
Gene Name
Product ID
S-CKO-18068
Gene Alias
1200013F24Rik; SRrp53
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rsrc1em1flox/Cya mice (Catalog S-CKO-18068) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000046542
NCBI RefSeq
NM_001356275
Target Region
Exon 4
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Rsrc1, or Arginine/serine‑rich coiled coil 1, is a gene significantly involved in mRNA constitutive and alternative splicing, as well as transcriptional regulation. It has been associated with various neurological disorders and cancers, indicating its broad biological importance. Genetic models, such as gene knockout (KO) or conditional knockout (CKO) mouse models, can potentially be used to further explore its functions [1,2,3].
In gastric cancer, RSRC1 functions as a tumor suppressor. Its downregulation in gastric cancer tissues is associated with poor patient prognosis. Knockdown of RSRC1 in gastric cancer cells promotes cell proliferation and migration, and it decreases the expression of the tumor suppressor gene PTEN [1].
In addition, RSRC1 loss-of-function variants cause mild to moderate autosomal recessive intellectual disability [2]. RSRC1 mutation in patients leads to aberrant splicing and transcription, downregulating IGFBP3, and causing an autosomal recessive syndrome of intellectual disability, aberrant behavior, hypotonia, and mild facial dysmorphism with normal brain MRI [3].
In conclusion, Rsrc1 plays crucial roles in multiple biological processes and disease conditions. Model-based research, especially through KO or CKO mouse models, has revealed its function as a tumor suppressor in gastric cancer and its association with intellectual disability. Understanding Rsrc1 contributes to a better comprehension of disease mechanisms in oncology and neurology.
References:
1. Yu, Shijun, Gautam, Nishim, Quan, Ming, Gao, Yong. 2019. RSRC1 suppresses gastric cancer cell proliferation and migration by regulating PTEN expression. In Molecular medicine reports, 20, 1747-1753. doi:10.3892/mmr.2019.10409. https://pubmed.ncbi.nlm.nih.gov/31257492/
2. Scala, Marcello, Mojarrad, Majid, Riazuddin, Saima, Houlden, Henry, Maroofian, Reza. . RSRC1 loss-of-function variants cause mild to moderate autosomal recessive intellectual disability. In Brain : a journal of neurology, 143, e31. doi:10.1093/brain/awaa070. https://pubmed.ncbi.nlm.nih.gov/32227164/
3. Perez, Yonatan, Menascu, Shay, Cohen, Idan, Yeger-Lotem, Esti, Birk, Ohad S. . RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3. In Brain : a journal of neurology, 141, 961-970. doi:10.1093/brain/awy045. https://pubmed.ncbi.nlm.nih.gov/29522154/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen