C57BL/6JCya-Eif4ebp2em1flox/Cya
Common Name
Eif4ebp2-flox
Product ID
S-CKO-18099
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-13688-Eif4ebp2-B6J-VB
When using this mouse strain in a publication, please cite “Eif4ebp2-flox Mouse (Catalog S-CKO-18099) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Eif4ebp2-flox
Strain ID
CKOCMP-13688-Eif4ebp2-B6J-VB
Gene Name
Product ID
S-CKO-18099
Gene Alias
2810011I19Rik, 4E-BP2, PHAS-II
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020288
NCBI RefSeq
NM_010124.2
Target Region
Exon 2~3
Size of Effective Region
~1.7 kb
Overview of Gene Research
Eif4ebp2, encoding the suppressor of mRNA translation initiation 4E-BP2, is a key component in the regulation of mRNA translation. It binds to eukaryotic initiation factor 4E (eIF4E), sequestering it and blocking cap-dependent translation, thus regulating cell growth and proliferation. It is involved in the mTORC1 signaling pathway, which is crucial for coordinating cell metabolism, growth, and survival in response to various stimuli [1,2,3].
In Eif4ebp2(-/-) mice, there is an imbalance in excitatory-to-inhibitory neurotransmission and ASD-like behaviors. These phenotypes can be reversed by antagonists of group I metabotropic glutamate receptors (mGluRs), suggesting that Eif4ebp2 plays a role in regulating synaptic physiology and behaviors relevant to autism spectrum disorders (ASDs) [4]. Also, in a study on cervical cancer, down-regulated circ_0000190 promotes cancer progression by weakening the binding ability of EIF4EBP2 to eIF4E, indicating its potential tumor-suppressive role [2].
In conclusion, Eif4ebp2 is essential for regulating mRNA translation, with implications in multiple biological processes. Gene-knockout mouse models, like Eif4ebp2(-/-) mice, have revealed its role in diseases such as ASDs and cervical cancer. These findings enhance our understanding of the molecular mechanisms underlying these diseases and may provide new therapeutic targets.
References：
1. Levy, Tal, Voeltzke, Kai, Hruby, Laura, Rotblat, Barak, Leprivier, Gabriel. 2024. mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. In Nature communications, 15, 4083. doi:10.1038/s41467-024-48386-y. https://pubmed.ncbi.nlm.nih.gov/38744825/
2. Yang, Chengcheng, Xie, Jia, Chen, Qian, Yang, Yisi. 2022. Down-regulated Circ_0000190 promotes cervical cancer by facilitating the activity of proto-oncogene protein EIF4E. In Cell cycle (Georgetown, Tex.), 21, 1349-1359. doi:10.1080/15384101.2021.2018212. https://pubmed.ncbi.nlm.nih.gov/35414334/
3. Aguilar-Valles, Argel, De Gregorio, Danilo, Matta-Camacho, Edna, Lacaille, Jean-Claude, Sonenberg, Nahum. 2020. Antidepressant actions of ketamine engage cell-specific translation via eIF4E. In Nature, 590, 315-319. doi:10.1038/s41586-020-03047-0. https://pubmed.ncbi.nlm.nih.gov/33328636/
4. Aguilar-Valles, Argel, Matta-Camacho, Edna, Khoutorsky, Arkady, Lacaille, Jean-Claude, Sonenberg, Nahum. . Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. In The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 11125-32. doi:10.1523/JNEUROSCI.4615-14.2015. https://pubmed.ncbi.nlm.nih.gov/26245973/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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