Adgrb3, also known as BAI3, belongs to the family of adhesion G protein-coupled receptors. It is highly expressed in the brain and plays roles in synaptogenesis, synapse maintenance, and may be involved in regulating aspects of the central nervous system such as axon guidance, myelination, and synapse formation. It has also been associated with several diseases, including schizophrenia, epilepsy, and cancer [1,2,3].

A mouse line with a 7-base pair deletion in Adgrb3 exon 10 was generated using Nuclease technology editing. Homozygous mutants lacked full-length ADGRB3 expression. These mutant mice showed reduced brain and body weights, deficits in social interaction, which indicates the role of Adgrb3 in these aspects. Since somatic mutations in Adgrb3 were identified in cancer patients, this mouse model can be used to explore whether loss of Adgrb3 function contributes to tumour development [2].

In conclusion, Adgrb3 is crucial for normal brain development and function as demonstrated by the gene-knockout mouse model. It is also associated with multiple disease conditions, especially those related to the nervous system and cancer. The Adgrb3-deficient mouse model provides a valuable tool for understanding its in-vivo physiological role in these disease areas.