C57BL/6JCya-Synpo2lem1flox/Cya
Common Name
Synpo2l-flox
Product ID
S-CKO-18589
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-68760-Synpo2l-B6J-VB
Status
When using this mouse strain in a publication, please cite “Synpo2l-flox Mouse (Catalog S-CKO-18589) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Synpo2l-flox
Strain ID
CKOCMP-68760-Synpo2l-B6J-VB
Gene Name
Product ID
S-CKO-18589
Gene Alias
Chap, 1110054M18Rik
Background
C57BL/6JCya
Gene Full Name
synaptopodin 2-like
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 14 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000117386
NCBI Transcript ID
NM_001310431
Target Region
Exon 4
Size of Effective Region
~2.6 kb
Overview of Gene Research
Synpo2l, or synaptopodin 2-like protein, is localized in the sarcomere of cardiomyocytes and is involved in heart morphogenesis. It contributes to actin bundle formation in cardiomyocytes by directly binding to α-actinin, which is crucial for sarcomere formation and maintenance [5].
In terms of diseases, multiple genome-wide association studies (GWAS) have linked Synpo2l to atrial fibrillation (AF). A specific splice site variant in Synpo2l was associated with an increased risk of AF [3]. Also, a missense variant in Synpo2l (rs3812629) at a known AF susceptibility locus showed a significant association with AF, though its causal relationship requires further evaluation [4]. Moreover, Synpo2l is among the genes identified in the GWAS meta-analysis of heart failure, suggesting its role in the pathogenesis of heart failure [2]. In colorectal cancer, Synpo2l is a core gene regulated by m6A. Mettl16 can regulate its mRNA stability, and Synpo2l promotes cancer cell lung metastasis by regulating COL10A1 secretion and attracting cancer-associated fibroblasts [1].
In conclusion, Synpo2l plays essential roles in cardiac structural development and function, with its dysfunction potentially contributing to atrial fibrillation and heart failure. In colorectal cancer, it is involved in the metastatic process. Studies on Synpo2l, especially through genetic models, help in understanding the molecular mechanisms of these diseases and may provide potential therapeutic targets.
References：
1. Wu, Jianlong, Ouyang, Peng, Huang, Rui, Wu, Wang, Li, Jian. 2024. METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the Cancer-Associated Fibroblasts. In International journal of biological sciences, 20, 4128-4145. doi:10.7150/ijbs.95375. https://pubmed.ncbi.nlm.nih.gov/39247832/
2. Shah, Sonia, Henry, Albert, Roselli, Carolina, Swerdlow, Daniel I, Lumbers, R Thomas. 2020. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. In Nature communications, 11, 163. doi:10.1038/s41467-019-13690-5. https://pubmed.ncbi.nlm.nih.gov/31919418/
3. Clausen, Alexander Guldmann, Vad, Oliver Bundgaard, Andersen, Julie Husted, Olesen, Morten Salling. 2021. Loss-of-Function Variants in the SYNPO2L Gene Are Associated With Atrial Fibrillation. In Frontiers in cardiovascular medicine, 8, 650667. doi:10.3389/fcvm.2021.650667. https://pubmed.ncbi.nlm.nih.gov/33768119/
4. Lubitz, Steven A, Brody, Jennifer A, Bihlmeyer, Nathan A, Ellinor, Patrick T, Lin, Honghuang. 2016. Whole Exome Sequencing in Atrial Fibrillation. In PLoS genetics, 12, e1006284. doi:10.1371/journal.pgen.1006284. https://pubmed.ncbi.nlm.nih.gov/27589061/
5. Yamada, Hiroshi, Osaka, Hirona, Tatsumi, Nanami, Naruse, Keiji, Takei, Kohji. 2024. Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes. In Cells, 13, . doi:10.3390/cells13161373. https://pubmed.ncbi.nlm.nih.gov/39195263/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
