PMF1, also known as polyamine modulated factor-1, is involved in polyamine homeostasis. Polyamines are important regulators of cell growth and death, suggesting that PMF1 may play a role in related biological processes. Additionally, in the context of plasmids, pMF1 in Myxococcus fulvus 124B02 contains genes related to plasmid maintenance and partitioning [1,3,5].

In bladder cancer, PMF1 hypermethylation is associated with gene expression loss, increasing tumor stage, and cytoplasmic PMF1 expression loss. Immunohistochemical analyses show its protein expression patterns are related to stage, grade, and overall survival. Also, PMF1 methylation in urinary specimens can distinguish bladder cancer patients from controls, indicating its potential in the clinical management of bladder cancer [2]. In a Chinese population study, the rs2984613 polymorphism in PMF1 was significantly associated with leukoaraiosis, suggesting its role in white matter lesions [4]. A pooled analysis for lacunar stroke found the SLC25A44-PMF1-BGLAP locus to be associated with cerebral white matter hyperintensities, providing insights into lacunar stroke pathogenesis [6].

In summary, PMF1 is involved in polyamine homeostasis and has implications in multiple disease areas. Studies on PMF1 in bladder cancer, leukoaraiosis, and lacunar-stroke-related white matter hyperintensities have revealed its potential role in disease progression and diagnosis. Understanding PMF1 can offer new perspectives on the underlying mechanisms of these diseases and potentially lead to novel diagnostic or therapeutic strategies.