C57BL/6JCya-Il7em1flox/Cya
Common Name:
Il7-flox
Product ID:
S-CKO-18856
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Il7-flox
Strain ID
CKOCMP-16196-Il7-B6J-VB
Gene Name
Product ID
S-CKO-18856
Gene Alias
A630026I06Rik; Il-7; hlb368
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Il7em1flox/Cya mice (Catalog S-CKO-18856) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000194279
NCBI RefSeq
NM_008371
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Interleukin-7 (IL7) is a cytokine belonging to the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors [2]. It plays a non-redundant role in T cell survival and homeostasis, and is also required for the development and homeostatic survival of lymphoid cells [1,2]. The major signals of IL7 receptor transduction are through JAK1, JAK3 to STAT5 and via non-canonical STAT3, STAT1, PI3K/AKT and MEK/ERK pathways [2].
IL7-deficient mice exhibit severe T cell lymphopenia, demonstrating the crucial role of IL7 in T cell maintenance [1]. In humans, deficiencies in the IL7 pathway lead to severe combined immunodeficiency due to lymphopenia [2]. Excessive IL7 pathway signaling in mice drives autoimmune diseases, and in humans, it is associated with autoimmune syndromes such as multiple sclerosis, type 1 diabetes, rheumatoid arthritis, sarcoidosis, atopic dermatitis, and asthma [2]. Mutations in the IL7 receptor pathway can drive acute lymphoblastic leukemia [2].
In conclusion, IL7 is essential for the survival of various lymphoid cells, especially T cells, and its dysregulation is associated with multiple diseases, including immunodeficiencies, autoimmune diseases, and leukemia. The study of IL7-deficient mouse models has significantly contributed to understanding its role in these disease conditions.
References:
1. Park, Jung-Hyun, Waickman, Adam T, Reynolds, Joseph, Castro, Mario, Molina-París, Carmen. 2019. IL7 receptor signaling in T cells: A mathematical modeling perspective. In Wiley interdisciplinary reviews. Systems biology and medicine, 11, e1447. doi:10.1002/wsbm.1447. https://pubmed.ncbi.nlm.nih.gov/31137085/
2. Winer, Hila, Rodrigues, Gisele O L, Hixon, Julie A, Li, Wenqing, Durum, Scott K. 2022. IL-7: Comprehensive review. In Cytokine, 160, 156049. doi:10.1016/j.cyto.2022.156049. https://pubmed.ncbi.nlm.nih.gov/36201890/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen