C57BL/6JCya-Marchf10em1flox/Cya
Common Name
Marchf10-flox
Product ID
S-CKO-19158
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-632687-Marchf10-B6J-VB
When using this mouse strain in a publication, please cite “Marchf10-flox Mouse (Catalog S-CKO-19158) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Marchf10-flox
Strain ID
CKOCMP-632687-Marchf10-B6J-VB
Gene Name
Product ID
S-CKO-19158
Gene Alias
4933417C16Rik, March10, Rnf190
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000049995
NCBI RefSeq
NM_172568
Target Region
Exon 5
Size of Effective Region
~1.2 kb
Overview of Gene Research
Marchf10, also known as Membrane-associated RING-CH-type finger 10, likely plays an important role in biological processes related to lipid metabolism [1]. However, the exact molecular functions, associated pathways, and overall biological importance are not comprehensively detailed in the provided abstract. Genetic models could potentially be valuable for further elucidating its functions.
In a study analyzing whole-exome (WES) and whole-genome sequencing (WGS) data of individuals with type 1 diabetes, the burden of protein-altering variants (PAVs) in Marchf10 was significantly associated with lipid phenotypes (p<2.9×10-6) [1]. This finding suggests that Marchf10 may be involved in the regulation of lipid metabolism, potentially offering insights into the genetic mechanisms underlying lipid-related disorders.
In conclusion, while the exact functions of Marchf10 are yet to be fully explored, the association of its PAVs with lipid phenotypes indicates its importance in lipid metabolism. Further research, perhaps through gene knockout (KO) or conditional knockout (CKO) mouse models, could potentially reveal more about its role in lipid-related diseases [1].
References：
1. Sandholm, Niina, Hotakainen, Ronja, Haukka, Jani K, Forsblom, Carol, Groop, Per-Henrik. 2022. Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations. In Genome medicine, 14, 132. doi:10.1186/s13073-022-01135-6. https://pubmed.ncbi.nlm.nih.gov/36419110/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.