C57BL/6JCya-Ankrd60em1flox/Cya
Common Name:
Ankrd60-flox
Product ID:
S-CKO-19288
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ankrd60-flox
Strain ID
CKOCMP-70065-Ankrd60-B6J-VB
Gene Name
Product ID
S-CKO-19288
Gene Alias
1700019A24Rik; 1700030G11Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ankrd60em1flox/Cya mice (Catalog S-CKO-19288) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000239457
NCBI RefSeq
NM_027303
Target Region
Exon 2
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Ankrd60, also known as ankyrin repeat domain 60, has been associated with multiple biological aspects. In humans, it is linked to body height [3]. Its role in specific pathways is yet to be fully elucidated, but its association with height indicates its importance in growth-related biological processes. Genetic models can potentially be valuable in further exploring its functions.
In Nordic Red cattle, Ankrd60 was identified as a candidate gene for the female fertility index (FTI) located on BTA13. Although it's not clear how this gene regulates female fertility, the majority of genes in similar studies were involved in protein binding [1].
In Icelandic horses, ANKRD60, along with other genes, was found in a genomic region associated with the conformation of back and croup. This region also influenced the quality of lateral gaits. Additionally, ANKRD60 is potentially linked to adolescent idiopathic scoliosis in humans [2].
In conclusion, Ankrd60 appears to be involved in diverse biological functions across different species. In cattle, it may play a role in female fertility, while in horses, it could be associated with body conformation and gait quality. In humans, it has connections to body height and potentially adolescent idiopathic scoliosis. Studies on Ankrd60 using genetic models can help further clarify its functions and contributions to these biological processes and potential disease areas. [1,2,3]
References:
1. Höglund, Johanna K, Buitenhuis, Bart, Guldbrandtsen, Bernt, Lund, Mogens S, Sahana, Goutam. 2015. Genome-wide association study for female fertility in Nordic Red cattle. In BMC genetics, 16, 110. doi:10.1186/s12863-015-0269-x. https://pubmed.ncbi.nlm.nih.gov/26369327/
2. Rosengren, Maria K, Sigurðardóttir, Heiðrún, Eriksson, Susanne, Solé, Marina, Lindgren, Gabriella. 2021. A QTL for conformation of back and croup influences lateral gait quality in Icelandic horses. In BMC genomics, 22, 267. doi:10.1186/s12864-021-07454-z. https://pubmed.ncbi.nlm.nih.gov/33853519/
3. Kim, Jae-Jung, Lee, Hae-In, Park, Taesung, Yoo, Han-Wook, Lee, Jong-Keuk. 2009. Identification of 15 loci influencing height in a Korean population. In Journal of human genetics, 55, 27-31. doi:10.1038/jhg.2009.116. https://pubmed.ncbi.nlm.nih.gov/19893584/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen