C57BL/6NCya-Ahrrem1/Cya
Common Name
Ahrr-KO
Product ID
S-KO-00967
Backgroud
C57BL/6NCya
Strain ID
KOCMP-11624-Ahrr-B6N-VA
When using this mouse strain in a publication, please cite “Ahrr-KO Mouse (Catalog S-KO-00967) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ahrr-KO
Strain ID
KOCMP-11624-Ahrr-B6N-VA
Gene Name
Product ID
S-KO-00967
Gene Alias
mKIAA1234
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022059
NCBI RefSeq
NM_009644
Target Region
Exon 6~8
Size of Effective Region
~4.4 kb
Overview of Gene Research
Ahrr, also known as Aryl-Hydrocarbon Receptor Repressor, is a key regulator in multiple biological processes. It participates in the aryl-hydrocarbon receptor (AHR) pathway, and its protein regulates cellular toxicity through the TCDD-mediated AHR pathway [1]. Ahrr is also involved in regulating cellular growth and differentiation, which are fundamental to lip and palatogenesis [1].
Ahrr-null (Ahrr-/-) mouse models have shown that AHRR deficiency reduces the representation of intestinal intraepithelial lymphocytes (IELs) in a cell-intrinsic manner, leading to increased oxidative stress, lipid peroxidation, and ferroptosis in IELs due to the unleashed AHR-induced expression of CYP1A1 [2]. In head and neck cancer, AHRR wild-type (Ahrr + / + ) transgenic mice develop tumors more frequently, suggesting that AHRR activates the EPAS1/VEGFD signaling axis to contribute to inflammatory lymphangiogenesis [3].
In conclusion, Ahrr plays essential roles in regulating cellular toxicity, growth, and differentiation. Studies using Ahrr-/-mouse models have revealed its significance in intestinal immune responses and cancer-related processes such as lymphangiogenesis, providing insights into the mechanisms underlying related diseases.
References:
1. Linnenkamp, Bianca Domit Werner, Raskin, Salmo, Esposito, Selene Elifio, Herai, Roberto Hirochi. 2020. A comprehensive analysis of AHRR gene as a candidate for cleft lip with or without cleft palate. In Mutation research. Reviews in mutation research, 785, 108319. doi:10.1016/j.mrrev.2020.108319. https://pubmed.ncbi.nlm.nih.gov/32800270/
2. Panda, Santosh K, Peng, Vincent, Sudan, Raki, Cella, Marina, Colonna, Marco. 2023. Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes. In Immunity, 56, 797-812.e4. doi:10.1016/j.immuni.2023.01.023. https://pubmed.ncbi.nlm.nih.gov/36801011/
3. Hu, An, Zhang, Jian-Wei, Yang, Li-Yun, Qiao, Pei-Pei, Lu, Dan. 2022. AHRR contributes to inflammatory lymphangiogenesis by activating the EPAS1/VEGFD signaling axis in head and neck cancer. In American journal of cancer research, 12, 537-548. doi:. https://pubmed.ncbi.nlm.nih.gov/35261785/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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