C57BL/6NCya-Compem1/Cya
Common Name:
Comp-KO
Product ID:
S-KO-01593
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Comp-KO
Strain ID
KOCMP-12845-Comp-B6N-VB
Gene Name
Product ID
S-KO-01593
Gene Alias
TSP5
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Compem1/Cya mice (Catalog S-KO-01593) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000003659
NCBI RefSeq
NM_016685
Target Region
Exon 5~10
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
COMP, also known as cartilage oligomeric matrix protein, is an extracellular matrix (ECM) glycoprotein. It is critical for collagen assembly and ECM stability, and has been associated with multiple fibrotic conditions. COMP regulates the TGF-β signaling pathway and may interact with membrane protein receptor CD36 to activate certain signaling pathways [1,2].
In a mouse model of chronic pancreatitis (CP), COMP was up-regulated in fibrotic tissues. Knockdown of COMP in human pancreatic stellate cells (HPSCs) inhibited their proliferation and migration, while recombinant human COMP (rCOMP) promoted HPSCs activation, potentially by promoting the phosphorylation of ERK and AKT through CD36 [1]. In Ang-II-induced atrial fibrillation in mice, silencing COMP inhibited the activation of the TGF-β pathway in atrial fibrillation cells [2]. In lung transplantation patients, higher mean COMP levels early after transplantation were associated with the development of restrictive allograft syndrome (RAS) [3]. In pseudoachondroplasia, mutations in COMP interfere with calcium-binding and protein conformation, leading to impaired chondrocyte function [4].
In conclusion, COMP plays essential roles in fibrosis-related processes, atrial fibrillation, and post-lung-transplantation complications. Studies using gene-knockdown or-knockout models have revealed its function in these disease conditions, highlighting its potential as a therapeutic target or biomarker.
References:
1. Wang, Yi, Li, Hai-Tao, Liu, Gang, Wang, Wen, Zeng, Xiang-Peng. 2024. COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways. In Cellular signalling, 118, 111135. doi:10.1016/j.cellsig.2024.111135. https://pubmed.ncbi.nlm.nih.gov/38479555/
2. Cai, XiaoBi, Li, Mingliang, Zhong, Ying, Yang, Wenkun, Liang, Zhu. 2023. COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-β Signaling Pathway. In Cardiovascular toxicology, 23, 305-316. doi:10.1007/s12012-023-09799-1. https://pubmed.ncbi.nlm.nih.gov/37584842/
3. Novo, Mirza, Westin, Johan, Andersson, Lars-Magnus, Nordén, Rickard, Magnusson, Jasper M. 2021. COMP: A Potential Early Biomarker of RAS After Lung Transplantation. In Transplantation direct, 7, e730. doi:10.1097/TXD.0000000000001189. https://pubmed.ncbi.nlm.nih.gov/34291152/
4. Posey, Karen L, Hayes, Elizabeth, Haynes, Richard, Hecht, Jacqueline T. . Role of TSP-5/COMP in pseudoachondroplasia. In The international journal of biochemistry & cell biology, 36, 1005-12. doi:. https://pubmed.ncbi.nlm.nih.gov/15094116/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen