C57BL/6NCya-Desem1/Cya
Common Name
Des-KO
Product ID
S-KO-01755
Backgroud
C57BL/6NCya
Strain ID
KOCMP-13346-Des-B6N-VA
Status
When using this mouse strain in a publication, please cite “Des-KO Mouse (Catalog S-KO-01755) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Des-KO
Strain ID
KOCMP-13346-Des-B6N-VA
Gene Name
Product ID
S-KO-01755
Gene Alias
--
Background
C57BL/6NCya
Gene Full Name
desmin
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 1 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000027409
NCBI Transcript ID
NM_010043
Target Region
Exon 2~7
Size of Effective Region
~3.2 kb
Overview of Gene Research
Des, also known as Diethylstilbestrol, is a synthetic non-steroidal oestrogen and endocrine-disrupting chemical. It was prescribed to pregnant women in the mid-20th century to prevent miscarriage, despite lack of proven efficacy. Its impact on biological systems is extensive as it can interfere with normal endocrine functions, which are crucial for maintaining physiological homeostasis [2,3,4].
The deleterious effects of Des are far-reaching. It has been classified as carcinogenic to humans since 2000. Women who took Des during pregnancy, as well as their children and grandchildren, have been affected. In-utero exposure to Des has been associated with an increased risk of cancers and structural abnormalities of the genital tract and breast in the exposed offspring. For example, DES daughters have a higher risk of uterine structural abnormalities that can affect pregnancy. Epidemiological studies in humans have also shown that DES grandchildren are at a higher risk of preterm birth, cerebral palsy, hypospadias in grandsons, and oesophageal atresia or tracheo-oesophageal fistula [1,2,3,4].
In conclusion, Des, a chemical once used during pregnancy, has had long-lasting and multi-generational harmful effects. Epidemiological studies in humans have been crucial in revealing its role in various adverse health outcomes, including cancers and pregnancy-related complications across generations. Understanding these effects helps in comprehending the long-term impacts of endocrine-disrupting chemicals on human health and can potentially guide future preventive strategies.
References:
1. Zamora-León, Pilar. 2021. Are the Effects of DES Over? A Tragic Lesson from the Past. In International journal of environmental research and public health, 18, . doi:10.3390/ijerph181910309. https://pubmed.ncbi.nlm.nih.gov/34639609/
2. . . Diethylstilbestrol (DES): also harms the third generation. In Prescrire international, 25, 294-298. doi:. https://pubmed.ncbi.nlm.nih.gov/30758926/
3. Al Jishi, Taher, Sergi, Consolato. 2017. Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring. In Reproductive toxicology (Elmsford, N.Y.), 71, 71-77. doi:10.1016/j.reprotox.2017.04.009. https://pubmed.ncbi.nlm.nih.gov/28461243/
4. Veurink, Marieke, Koster, Marlies, Berg, Lolkje T W de Jong-van den. . The history of DES, lessons to be learned. In Pharmacy world & science : PWS, 27, 139-43. doi:. https://pubmed.ncbi.nlm.nih.gov/16096877/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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