C57BL/6NCya-Emdem1/Cya
Common Name:
Emd-KO
Product ID:
S-KO-01869
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Emd-KO
Strain ID
KOCMP-13726-Emd-B6N-VA
Gene Name
Product ID
S-KO-01869
Gene Alias
Sta
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
X
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Emdem1/Cya mice (Catalog S-KO-01869) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000002029
NCBI RefSeq
NM_007927
Target Region
Exon 1~6
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Emd, also known as Emerin, is a skeletal protein. Abnormal nuclear structure caused by its dysregulation is common in tumour cells. It has been found to play a role in glucose metabolism, where it promotes glycolysis and inhibits aerobic oxidation in lung adenocarcinoma by interacting with PDHA [1].
In lung adenocarcinoma, Emd was highly expressed, and its high expression promoted malignant phenotypes. The ISGylation at lysine 37 of Emd inhibited lysine 36 ubiquitination, upregulating Emd stability. Emd bound with PDHA, stimulating serine 293 and 300 phosphorylation, inhibiting PDHA expression, and facilitating glycolysis of glucose that should enter the aerobic oxidation pathway. In clinical specimens, Emd was negatively associated with PDHA, while positively associated with Emd ISGylation, tumour stage, and diameter [1].
In conclusion, Emd is a significant protein in the context of lung adenocarcinoma, with its role in glucose metabolism—specifically inhibiting aerobic oxidation—being a key finding. Understanding Emd's function in this disease through such research can potentially provide new strategies for lung adenocarcinoma treatment.
References:
1. Zhang, Congcong, Cui, Jiangtao, Cao, Leiqun, Xia, Jinjing, Zhang, Xiao. 2022. ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma. In Journal of cellular and molecular medicine, 26, 5078-5094. doi:10.1111/jcmm.17536. https://pubmed.ncbi.nlm.nih.gov/36071546/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen