C57BL/6NCya-Cd209aem1/Cya
Common Name:
Cd209a-KO
Product ID:
S-KO-03000
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cd209a-KO
Strain ID
KOCMP-170786-Cd209a-B6N-VA
Gene Name
Product ID
S-KO-03000
Gene Alias
CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1; Dcsign; SIGN-R1; SIGNR5
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Cd209aem1/Cya mice (Catalog S-KO-03000) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000012847
NCBI RefSeq
NM_133238
Target Region
Exon 1~6
Size of Effective Region
~3.7 kb
Detailed Document
Overview of Gene Research
Cd209a, also known as SIGNR5, is a C-type lectin receptor (CLR) related to human DC-SIGN. It plays crucial roles in immune-related processes. Cd209a can interact with other receptors like Dectin-2 and Mincle, and is involved in signaling pathways such as Raf-1 activation. It is significant in driving immunopathology in certain diseases and has potential in antigen-delivery-mediated adaptive immunity [1,3,4].
In schistosome-induced immunopathology, CD209a-deficient CBA mice show decreased Th17 responses and are protected from severe immunopathology. CD209a augments egg-induced IL-1β and IL-23 production initiated by Dectin-2 and Mincle in vitro [1]. In Helicobacter pylori infection, CD209a mediates LECT2-induced maturation and cytokine secretion in bone marrow-derived dendritic cells (BMDCs), with LECT2 acting via the CD209a-JNK/P38 MAPK pathway [2]. Also, LECT2 protects mice from bacterial sepsis by activating macrophages through the CD209a receptor [5].
In conclusion, Cd209a is a key player in immune-mediated disease processes. Gene-knockout mouse models, especially in schistosomiasis, H. pylori infection, and bacterial sepsis, have revealed its importance in driving Th17-mediated immunopathology, modulating dendritic cell function, and activating macrophages. Understanding Cd209a's function can provide insights into the mechanisms of these diseases and potential therapeutic strategies [1,2,5].
References:
1. Kalantari, Parisa, Morales, Yoelkys, Miller, Emily A, Bunnell, Stephen C, Stadecker, Miguel J. . CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. In Cell reports, 22, 1288-1300. doi:10.1016/j.celrep.2018.01.001. https://pubmed.ncbi.nlm.nih.gov/29386115/
2. Zhang, Xiaofen, Sun, Kefang, Tang, Chenxi, Yu, Chaohui, Li, Lan. 2023. LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor. In Journal of gastroenterology and hepatology, 38, 625-633. doi:10.1111/jgh.16138. https://pubmed.ncbi.nlm.nih.gov/36740832/
3. Ponichtera, Holly E, Shainheit, Mara G, Liu, Beiyun C, Hacohen, Nir, Stadecker, Miguel J. 2014. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. In Journal of immunology (Baltimore, Md. : 1950), 192, 4655-65. doi:10.4049/jimmunol.1400121. https://pubmed.ncbi.nlm.nih.gov/24729611/
4. Schetters, Sjoerd T T, Kruijssen, Laura J W, Crommentuijn, Matheus H W, Garcia-Vallejo, Juan J, van Kooyk, Yvette. 2018. Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity. In Frontiers in immunology, 9, 990. doi:10.3389/fimmu.2018.00990. https://pubmed.ncbi.nlm.nih.gov/29867967/
5. Lu, Xin-Jiang, Chen, Jiong, Yu, Chao-Hui, Zhang, Shun, Xu, Lei. 2012. LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor. In The Journal of experimental medicine, 210, 5-13. doi:10.1084/jem.20121466. https://pubmed.ncbi.nlm.nih.gov/23254286/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen