C57BL/6JCya-Ptprgem1/Cya
Common Name
Ptprg-KO
Product ID
S-KO-03928
Backgroud
C57BL/6JCya
Strain ID
KOCMP-19270-Ptprg-B6J-VB
When using this mouse strain in a publication, please cite “Ptprg-KO Mouse (Catalog S-KO-03928) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ptprg-KO
Strain ID
KOCMP-19270-Ptprg-B6J-VB
Gene Name
Product ID
S-KO-03928
Gene Alias
5430405N12Rik, RPTPgamma
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000248537
NCBI RefSeq
NM_008981
Target Region
Exon 15
Size of Effective Region
~1.0 kb
Overview of Gene Research
Ptprg, or Protein Tyrosine Phosphatase Receptor Type G, is known to interact with and regulate several tyrosine kinases. It contains a carbonic anhydrase-like domain (CAH) and a fibronectin type III domain in the N-terminal portion, which are associated with its role as a [HCO3-] sensor in vascular and renal tissues and a possible interaction domain for cell adhesion respectively. It has been implicated in various biological processes and diseases, with its ligands including the contactins family (CNTN) [2].
In Alzheimer's disease (AD), single-cell and spatial transcriptomics studies found that a microglia subpopulation Mic_PTPRG can communicate with specific neurons, causing them to express PTPRG. In neurons, PTPRG binds and upregulates the m6A methyltransferase VIRMA, inhibiting the translation of PRKN mRNA and suppressing mitophagy. As the disease progresses, this leads to the reprogramming of energy and nutrient metabolic pathways in neurons, ultimately resulting in their death [1].
In summary, Ptprg plays a role in cell signaling regulation, potentially acting as an [HCO3-] sensor and cell adhesion mediator. In AD, its interaction with VIRMA in neurons affects mitophagy and neuronal survival. These findings from model-based research, such as the studies in AD mouse models, enhance our understanding of Ptprg's functions in normal and disease-related biological processes.
References:
1. Zou, Donghua, Huang, Xiaohua, Lan, Yating, Mao, Yingwei, Luo, Jiefeng. 2024. Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer's disease. In Pharmacological research, 201, 107098. doi:10.1016/j.phrs.2024.107098. https://pubmed.ncbi.nlm.nih.gov/38325728/
2. Boni, Christian, Laudanna, Carlo, Sorio, Claudio. 2022. A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease. In Biomolecules, 12, . doi:10.3390/biom12010084. https://pubmed.ncbi.nlm.nih.gov/35053232/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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