Thbs3, short for thrombospondin 3, is an adhesive glycoprotein belonging to the thrombospondin gene family. It is involved in cell-cell and cell-matrix interactions [1]. The Thbs3 gene shows a unique expression pattern with high levels in the lung [6]. It may participate in multiple biological processes, and its dysregulation is associated with various diseases [1,3,4,5,7,8].

In acute myocardial infarction (AMI), low THBS3 expression in peripheral blood is related to AMI and is an independent risk factor, potentially serving as a novel biomarker for early detection [1]. In pseudorabies virus (PRV) infection, THBS3 acts as a new PRV coreceptor, interacting with PRV gD to facilitate virus attachment, fusion, and entry [2]. In clear cell renal cell carcinoma (ccRCC), elevated THBS3 expression predicts poor overall survival and is closely related to immunity [4]. Additionally, in gout, THBS3 is among the genes potentially associated with the disease, and increased expression may be related to a reduced gout risk [3,7].

In conclusion, Thbs3 plays important roles in cell-related interactions and is associated with multiple diseases such as AMI, PRV-related infections, ccRCC, and gout. These disease-related associations suggest that understanding Thbs3 function could provide insights into disease mechanisms and potential therapeutic strategies. [1,2,3,4,7]

References:

1. Chen, Yanqiu, Meng, Heyu, Meng, Xin, Wang, Jingru, Meng, Fanbo. . Correlation Between Low THBS3 Expression in Peripheral Blood and Acute Myocardial Infarction. In Frontiers in bioscience (Landmark edition), 27, 291. doi:10.31083/j.fbl2710291. https://pubmed.ncbi.nlm.nih.gov/36336864/

2. Pan, Yudi, Guo, Longjun, Miao, Qian, Tian, Jin, Feng, Li. 2023. Association of THBS3 with Glycoprotein D Promotes Pseudorabies Virus Attachment, Fusion, and Entry. In Journal of virology, 97, e0187122. doi:10.1128/jvi.01871-22. https://pubmed.ncbi.nlm.nih.gov/36648234/

3. Yang, Yubiao, Hu, Ping, Zhang, Qinnan, Hao, Jian, Zhou, Xianhu. 2024. Single-cell and genome-wide Mendelian randomization identifies causative genes for gout. In Arthritis research & therapy, 26, 114. doi:10.1186/s13075-024-03348-z. https://pubmed.ncbi.nlm.nih.gov/38831441/

4. Wang, Gang, Qu, Fangfang, Zhou, Jincai, Zhu, Bingye, Gao, Yulong. 2022. Elevated THBS3 predicts poor overall survival for clear cell renal cell carcinoma and identifies LncRNA/RBP/THBS3 mRNA networks. In Cell cycle (Georgetown, Tex.), 22, 316-330. doi:10.1080/15384101.2022.2117910. https://pubmed.ncbi.nlm.nih.gov/36045611/

5. Carvalho, Robson Francisco, do Canto, Luisa Matos, Abildgaard, Cecilie, Steffensen, Karina Dahl, Rogatto, Silvia Regina. 2022. Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer. In Cell communication and signaling : CCS, 20, 176. doi:10.1186/s12964-022-00991-4. https://pubmed.ncbi.nlm.nih.gov/36352420/

6. Vos, H L, Devarayalu, S, de Vries, Y, Bornstein, P. . Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family. In The Journal of biological chemistry, 267, 12192-6. doi:. https://pubmed.ncbi.nlm.nih.gov/1601886/

7. Wang, Yu, Chen, Jiahao, Yao, Hang, Xu, Xiaogang, Zhang, Delin. 2024. Mendelian randomization analysis identified potential genes pleiotropically associated with gout. In Frontiers in genetics, 15, 1426860. doi:10.3389/fgene.2024.1426860. https://pubmed.ncbi.nlm.nih.gov/39161423/

8. Loktionov, Alexey Valerevich, Kobzeva, Ksenia Andreevna, Karpenko, Andrey Romanovich, Orlov, Yuriy Lvovich, Bushueva, Olga Yurievna. 2024. GWAS-significant loci and severe COVID-19: analysis of associations, link with thromboinflammation syndrome, gene-gene, and gene-environmental interactions. In Frontiers in genetics, 15, 1434681. doi:10.3389/fgene.2024.1434681. https://pubmed.ncbi.nlm.nih.gov/39175753/