Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Vdac1em1/Cya
Common Name:
Vdac1-KO
Product ID:
S-KO-05680
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Vdac1-KO
Strain ID
KOCMP-22333-Vdac1-B6J-VA
Gene Name
Vdac1
Product ID
S-KO-05680
Gene Alias
Vdac5; mVDAC1; mVDAC5
Background
C57BL/6JCya
NCBI ID
22333
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:106919
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vdac1em1/Cya mice (Catalog S-KO-05680) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102758
NCBI RefSeq
NM_011694
Target Region
Exon 4~5
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Vdac1, also known as voltage-dependent anion channel 1, is a crucial regulator of mitochondrial function, acting as a mitochondrial gatekeeper. It is located in the outer mitochondrial membrane and is involved in multiple key cellular processes, such as controlling energy sources, metabolism, epigenomic elements, apoptosis, endoplasmic reticulum-mitochondria cross-talk, autophagy, and inflammation [1]. It interacts with over 100 proteins, orchestrating mitochondrial and cellular activities through various signaling pathways.

In Alzheimer's disease (AD), Vdac1 is overexpressed post-mortem in patients' brains and in amyloid precursor protein (APP) transgenic mice. Targeting Vdac1 with VBIT-4 in a 5×FAD mouse model of AD prevented associated pathophysiological changes like neuronal cell death, neuroinflammation, and cognitive decline, suggesting Vdac1 as a potential therapeutic target for AD [2,5]. In liver fibrosis, Parkin-mediated site-specific ubiquitination of Vdac1 at lysine 53 interrupted Vdac1 oligomerization and mitochondrial DNA release, with Parkin knockout aggravating the effects, indicating the importance of Vdac1 regulation in liver fibrosis [3]. In inflammatory bowel disease, Vdac1 is overexpressed in the colon of patients and DSS-treated mice. Treatment with VBIT-12, a Vdac1-interacting molecule, suppressed various symptoms of inflammation and apoptosis in DSS-treated mice [4].

In conclusion, Vdac1 is essential for maintaining mitochondrial function and is involved in numerous cellular processes. Model-based research, especially using mouse models, has revealed its significance in diseases such as Alzheimer's disease, liver fibrosis, and inflammatory bowel disease. These studies suggest that targeting Vdac1 could be a promising strategy for treating these diseases.

References:

1. Shoshan-Barmatz, Varda, Shteinfer-Kuzmine, Anna, Verma, Ankit. 2020. VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases. In Biomolecules, 10, . doi:10.3390/biom10111485. https://pubmed.ncbi.nlm.nih.gov/33114780/

2. Shoshan-Barmatz, Varda, Nahon-Crystal, Edna, Shteinfer-Kuzmine, Anna, Gupta, Rajeev. 2018. VDAC1, mitochondrial dysfunction, and Alzheimer's disease. In Pharmacological research, 131, 87-101. doi:10.1016/j.phrs.2018.03.010. https://pubmed.ncbi.nlm.nih.gov/29551631/

3. Wu, Ne N, Wang, Lifeng, Wang, Lu, Zhang, Yingmei, Ren, Jun. 2023. Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis. In Experimental & molecular medicine, 55, 269-280. doi:10.1038/s12276-022-00923-9. https://pubmed.ncbi.nlm.nih.gov/36658227/

4. Verma, Ankit, Pittala, Srinivas, Alhozeel, Belal, Chung, Jay H, Shoshan-Barmatz, Varda. 2021. The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target. In Molecular therapy : the journal of the American Society of Gene Therapy, 30, 726-744. doi:10.1016/j.ymthe.2021.06.024. https://pubmed.ncbi.nlm.nih.gov/34217890/

5. Verma, Ankit, Shteinfer-Kuzmine, Anna, Kamenetsky, Nikita, Knafo, Shira, Shoshan-Barmatz, Varda. 2022. Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer's disease protects against mitochondrial dysfunction and mitigates brain pathology. In Translational neurodegeneration, 11, 58. doi:10.1186/s40035-022-00329-7. https://pubmed.ncbi.nlm.nih.gov/36578022/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest