C57BL/6JCya-Oosp3em1/Cya
Common Name:
Oosp3-KO
Product ID:
S-KO-05918
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Oosp3-KO
Strain ID
KOCMP-225923-Oosp3-B6J-VA
Gene Name
Product ID
S-KO-05918
Gene Alias
Gm97
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Oosp3em1/Cya mice (Catalog S-KO-05918) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000069760
NCBI RefSeq
NM_001033283
Target Region
Exon 2~5
Size of Effective Region
~6.1 kb
Detailed Document
Overview of Gene Research
Oosp3 is a member of the Oosp family genes. These genes have expression patterns linked to the female reproductive system, yet their exact functions in oogenesis or fertilization had been unclear. Genetic models like knockout mice can be valuable tools to study its function [1].
A study generating Nuclease technology knockout (KO) mice found that knocking out three Oosp family genes (Oosp1, Oosp2, and Oosp3) resulted in triple KO (TKO) mutant mice with decreased prolificacy but not infertility. This indicates that Oosp3, along with Oosp1 and Oosp2, may potentially be dispensable for female fertility [1].
In conclusion, through KO mouse model-based research, Oosp3 has been shown to potentially not be essential for female fertility, despite its expression in the female reproductive system. These findings contribute to understanding the genetic factors influencing female fertility and may prevent unnecessary in-vitro studies on the assumed essentiality of these genes for fertility [1].
References:
1. Abbasi, Ferheen, Kodani, Mayo, Emori, Chihiro, Fujihara, Yoshitaka, Ikawa, Masahito. 2020. Nuclease technology-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice. In Cells, 9, . doi:10.3390/cells9040821. https://pubmed.ncbi.nlm.nih.gov/32231122/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen