C57BL/6JCya-Oosp3em1/Cya
Common Name
Oosp3-KO
Product ID
S-KO-05918
Backgroud
C57BL/6JCya
Strain ID
KOCMP-225923-Oosp3-B6J-VA
When using this mouse strain in a publication, please cite “Oosp3-KO Mouse (Catalog S-KO-05918) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Oosp3-KO
Strain ID
KOCMP-225923-Oosp3-B6J-VA
Gene Name
Product ID
S-KO-05918
Gene Alias
Gm97
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000069760
NCBI RefSeq
NM_001033283
Target Region
Exon 2~5
Size of Effective Region
~6.1 kb
Overview of Gene Research
Oosp3 is a member of the Oosp family genes. These genes have expression patterns linked to the female reproductive system, yet their exact functions in oogenesis or fertilization had been unclear. Genetic models like knockout mice can be valuable tools to study its function [1].
A study generating CRISPR/Cas9 knockout (KO) mice found that knocking out three Oosp family genes (Oosp1, Oosp2, and Oosp3) resulted in triple KO (TKO) mutant mice with decreased prolificacy but not infertility. This indicates that Oosp3, along with Oosp1 and Oosp2, may potentially be dispensable for female fertility [1].
In conclusion, through KO mouse model-based research, Oosp3 has been shown to potentially not be essential for female fertility, despite its expression in the female reproductive system. These findings contribute to understanding the genetic factors influencing female fertility and may prevent unnecessary in-vitro studies on the assumed essentiality of these genes for fertility [1].
References:
1. Abbasi, Ferheen, Kodani, Mayo, Emori, Chihiro, Fujihara, Yoshitaka, Ikawa, Masahito. 2020. CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice. In Cells, 9, . doi:10.3390/cells9040821. https://pubmed.ncbi.nlm.nih.gov/32231122/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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