Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Dock6em1/Cya
Common Name:
Dock6-KO
Product ID:
S-KO-09207
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Dock6-KO
Strain ID
KOCMP-319899-Dock6-B6J-VA
Gene Name
Dock6
Product ID
S-KO-09207
Gene Alias
2410095B20Rik; 4931431C02Rik; C330023D02Rik; mKIAA1395
Background
C57BL/6JCya
NCBI ID
319899
Modification
Conventional knockout
Chromosome
9
Phenotype
MGI:1914789
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dock6em1/Cya mice (Catalog S-KO-09207) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000217336
NCBI RefSeq
NM_177030
Target Region
Exon 6~7
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Dock6, a guanine nucleotide exchange factor (GEF) for Rac1 and CDC42, is involved in regulating the activity of RHO-GTPases, which play crucial roles in cell migration, adhesion, and cytoskeletal organization. It is associated with the WNT/β -catenin signaling pathway, a key regulator in embryonic development and tissue homeostasis [1].

Mutations in the DOCK6 gene are responsible for an autosomal-recessive variant of Adams-Oliver syndrome. This syndrome is characterized by aplasia cutis congenita, terminal transverse limb defects, along with brain and eye anomalies, and intellectual disability [2,4,5]. In cancer, elevated DOCK6 expression in gastric cancer is linked to chemo-and radioresistance, and it promotes cancer stem cell characteristics through Rac1 activation. In oral squamous cell cancer, overexpression of DOCK6 promotes cellular migration and invasion and is associated with poor prognosis [1,3].

In conclusion, Dock6 is essential for normal development as demonstrated by its role in Adams-Oliver syndrome. In cancer, it has significant implications for tumor progression, resistance to treatment, and prognosis. Studies on Dock6, especially through gene-related disease models, help in understanding its role in these biological processes and diseases, potentially leading to new therapeutic strategies.

References:

1. Chi, Hsiang-Cheng, Tsai, Chung-Ying, Wang, Chia-Siu, Chen, Wei-Jan, Lin, Kwang-Huei. 2020. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. In Oncogene, 39, 5933-5949. doi:10.1038/s41388-020-01390-0. https://pubmed.ncbi.nlm.nih.gov/32753649/

2. Zepeda-Romero, Luz Consuelo, Zenker, Martin, Schanze, Denny, Corona-Rivera, Alfredo, Corona-Rivera, Jorge Román. 2022. Intrafamilial phenotypic variability in autosomal recessive DOCK6-related Adams-Oliver syndrome. In European journal of medical genetics, 65, 104653. doi:10.1016/j.ejmg.2022.104653. https://pubmed.ncbi.nlm.nih.gov/36330903/

3. Zhang, Ze-Ying, Sun, Yuan-Yuan, Wang, He-Chen, Fu, Wei-Neng, Sun, Chang-Fu. 2021. Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis. In Archives of oral biology, 133, 105297. doi:10.1016/j.archoralbio.2021.105297. https://pubmed.ncbi.nlm.nih.gov/34742001/

4. Sukalo, Maja, Tilsen, Felix, Kayserili, Hülya, Southgate, Laura, Zenker, Martin. 2015. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies. In Human mutation, 36, 593-8. doi:10.1002/humu.22795. https://pubmed.ncbi.nlm.nih.gov/25824905/

5. Nieto-Benito, Lula Maria, Suárez-Fernández, Ricardo, Campos-Domínguez, Minia. 2023. A novel pathogenic variation of DOCK6 gene: the genotype-phenotype correlation in Adams-Oliver syndrome. In Molecular biology reports, 50, 5519-5521. doi:10.1007/s11033-023-08430-4. https://pubmed.ncbi.nlm.nih.gov/37133614/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest