Adissp, also known as UPF0687 protein or human C20orf27 homolog, is an adipokine. It is a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis. It functions through a pathway where it binds to a putative receptor on adipocyte surface and activates protein kinase A independently of β -adrenergic signaling. Its study is crucial as it offers potential for treating obesity and diabetes [1].

Adipose-specific Adissp knockout mice show defective WAT browning, and are more prone to high-fat diet-induced obesity and hyperglycemia. This reveals that Adissp is essential for WAT browning and maintaining normal glucose levels and body weight [1].

In conclusion, Adissp is a major upstream signaling component in adipose thermogenesis. The Adissp knockout mouse model has demonstrated its significance in preventing obesity and hyperglycemia, highlighting its potential as a target for treating these metabolic disorders [1].

References:

1. Chen, Qingbo, Huang, Lei, Pan, Dongning, Guertin, David A, Wang, Yong-Xu. 2022. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. In Nature communications, 13, 7633. doi:10.1038/s41467-022-35335-w. https://pubmed.ncbi.nlm.nih.gov/36496438/