C57BL/6NCya-Adisspem1/Cya
Common Name
Adissp-KO
Product ID
S-KO-12223
Backgroud
C57BL/6NCya
Strain ID
KOCMP-67326-Adissp-B6N-VA
When using this mouse strain in a publication, please cite “Adissp-KO Mouse (Catalog S-KO-12223) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Adissp-KO
Strain ID
KOCMP-67326-Adissp-B6N-VA
Gene Name
Product ID
S-KO-12223
Gene Alias
1700037H04Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000103188
NCBI RefSeq
NM_026091
Target Region
Exon 2
Size of Effective Region
~0.1 kb
Overview of Gene Research
Adissp, also known as UPF0687 protein or human C20orf27 homolog, is an adipokine. It is a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis. It functions through a pathway where it binds to a putative receptor on adipocyte surface and activates protein kinase A independently of β -adrenergic signaling. Its study is crucial as it offers potential for treating obesity and diabetes [1].
Adipose-specific Adissp knockout mice show defective WAT browning, and are more prone to high-fat diet-induced obesity and hyperglycemia. This reveals that Adissp is essential for WAT browning and maintaining normal glucose levels and body weight [1].
In conclusion, Adissp is a major upstream signaling component in adipose thermogenesis. The Adissp knockout mouse model has demonstrated its significance in preventing obesity and hyperglycemia, highlighting its potential as a target for treating these metabolic disorders [1].
References:
1. Chen, Qingbo, Huang, Lei, Pan, Dongning, Guertin, David A, Wang, Yong-Xu. 2022. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. In Nature communications, 13, 7633. doi:10.1038/s41467-022-35335-w. https://pubmed.ncbi.nlm.nih.gov/36496438/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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