C57BL/6NCya-Rreb1em1/Cya
Common Name
Rreb1-KO
Product ID
S-KO-12828
Backgroud
C57BL/6NCya
Strain ID
KOCMP-68750-Rreb1-B6N-VA
When using this mouse strain in a publication, please cite “Rreb1-KO Mouse (Catalog S-KO-12828) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Rreb1-KO
Strain ID
KOCMP-68750-Rreb1-B6N-VA
Gene Name
Product ID
S-KO-12828
Gene Alias
1110037N09Rik, B930013M22Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000037232
NCBI RefSeq
XM_006516756
Target Region
Exon 8~9
Size of Effective Region
~4.4 kb
Overview of Gene Research
Rreb1, the Ras-responsive element binding protein 1, is a zinc finger transcription factor. It is widely involved in biological processes such as cell proliferation, transcriptional regulation, and DNA damage repair. The activation of Rreb1 is regulated by the MAPK pathway, and it has been associated with multiple signaling pathways including the TGF-β pathway, playing a vital role in development, fibrosis, and cancer [1]. Genetic models, like KO or CKO mouse models, can be valuable for studying its functions.
In a mouse model where a nervous system-enriched Rreb1 transcript was spontaneously mutated, there was a progressive loss of cerebellar Purkinje cells and ataxia. Analysis revealed dysregulation of Rreb1 targets related to the microtubule cytoskeleton and endomembrane system, demonstrating its role in maintaining the microtubule network and proteostasis in neurons [2]. In another mouse model, knockdown of Rreb1 in Sertoli cells caused impaired cell development, defective blood-testis barrier structure, and abnormal spermatogenesis, indicating its importance in Sertoli cell maturation, function, and spermatogenesis [3].
In conclusion, Rreb1 is a key transcription factor essential for multiple biological processes. Model-based research, especially KO/CKO mouse models, has revealed its significance in neuronal homeostasis, spermatogenesis, and other processes. These findings contribute to understanding diseases related to neuronal and reproductive systems, as well as cancers where Rreb1 has been implicated [2-3, 5, 9].
References:
1. Deng, Ya-Nan, Xia, Zijing, Zhang, Peng, Ejaz, Samina, Liang, Shufang. 2020. Transcription Factor RREB1: from Target Genes towards Biological Functions. In International journal of biological sciences, 16, 1463-1473. doi:10.7150/ijbs.40834. https://pubmed.ncbi.nlm.nih.gov/32210733/
2. Griffin, Emily N, Jucius, Thomas, Sim, Su-Eon, Heinz, Sven, Ackerman, Susan L. 2024. RREB1 regulates neuronal proteostasis and the microtubule network. In Science advances, 10, eadh3929. doi:10.1126/sciadv.adh3929. https://pubmed.ncbi.nlm.nih.gov/38198538/
3. Wu, Zhu, Chen, Xu, Yan, Tong, Zheng, Meimei, Zhu, Hui. 2024. Rreb1 is a key transcription factor in Sertoli cell maturation and function and spermatogenesis in mouse. In Zygote (Cambridge, England), 32, 130-138. doi:10.1017/S0967199423000655. https://pubmed.ncbi.nlm.nih.gov/38248872/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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