C57BL/6JCya-Slc16a13em1/Cya
Common Name:
Slc16a13-KO
Product ID:
S-KO-13022
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc16a13-KO
Strain ID
KOCMP-69309-Slc16a13-B6J-VA
Gene Name
Product ID
S-KO-13022
Gene Alias
1700007D07Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc16a13em1/Cya mice (Catalog S-KO-13022) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000060010
NCBI RefSeq
NM_172371
Target Region
Exon 1~4
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Slc16a13, also known as monocarboxylate transporter 13 (MCT13), is a gene encoding a member of the solute carrier 16 family of monocarboxylate transporters. It is expressed in the liver and duodenum, and is a susceptibility gene for type 2 diabetes. Its functions may involve the transport of oligopeptides and peptidomimetics across the plasma membrane, potentially contributing to the regulation of intestinal epithelial transport [1].
Genome-wide association studies have identified SLC16A13 as a type 2 diabetes-related gene. In a mouse model, deletion of Slc16a13 led to reduced hepatic lipid accumulation and increased hepatic insulin sensitivity in high-fat diet-fed mice. This was due to reduced intrahepatocellular lactate availability, which increased AMPK activation and mitochondrial respiration, while reducing hepatic lipid content and attenuating hepatic diacylglycerol-PKCε mediated insulin resistance [2].
In conclusion, Slc16a13 plays a role in the transport of oligopeptides and is associated with type 2 diabetes. The gene knockout mouse model has revealed its significance in regulating hepatic lipid metabolism and insulin sensitivity, suggesting that Slc16a13 could be a potential target for the treatment of type 2 diabetes and non-alcoholic fatty liver disease [2].
References:
1. Higuchi, Kei, Kunieda, Misato, Sugiyama, Koki, Kishimoto, Hisanao, Inoue, Katsuhisa. 2023. Monocarboxylate Transporter 13 (MCT13/SLC16A13) Functions as a Novel Plasma Membrane Oligopeptide Transporter. In Nutrients, 15, . doi:10.3390/nu15163527. https://pubmed.ncbi.nlm.nih.gov/37630718/
2. Schumann, Tina, König, Jörg, von Loeffelholz, Christian, Hamilton, Bradford S, Birkenfeld, Andreas L. 2021. Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. In Communications biology, 4, 826. doi:10.1038/s42003-021-02279-8. https://pubmed.ncbi.nlm.nih.gov/34211098/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen