C57BL/6JCya-Wwp1em1/Cya
Common Name
Wwp1-KO
Product ID
S-KO-15881
Backgroud
C57BL/6JCya
Strain ID
KOCMP-107568-Wwp1-B6J-VB
When using this mouse strain in a publication, please cite “Wwp1-KO Mouse (Catalog S-KO-15881) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Wwp1-KO
Strain ID
KOCMP-107568-Wwp1-B6J-VB
Gene Name
Product ID
S-KO-15881
Gene Alias
8030445B08Rik, AIP5, SDRP1, Tiul1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000108246
NCBI RefSeq
NM_177327
Target Region
Exon 5
Size of Effective Region
~0.1 kb
Overview of Gene Research
WWP1, also known as WW Domain-containing E3 Ubiquitin Protein Ligase 1, is a member of the HECT E3 ligase family. It exerts functions through ubiquitination or protein-protein interaction with PPXY-containing proteins. WWP1 is involved in multiple physiological processes such as development, cell growth, apoptosis, and differentiation, and is thus of great biological importance. Genetic models, like KO/CKO mouse models, are valuable for studying its functions [1,4].
In KO mouse models, WWP1 knockout protected the heart from transverse aortic constriction (TAC)-induced hypertrophy, suggesting its role in pressure overload-induced cardiac remodeling. The mechanism involves WWP1 promoting K27-linked polyubiquitination of DVL2, exacerbating cardiac hypertrophy via the DVL2/CaMKII/HDAC4/MEF2C pathway [2]. In cancer, genetic ablation or pharmacological inhibition of WWP1 triggered PTEN reactivation, unleashing its tumor-suppressive activity, indicating WWP1's role in MYC-driven tumorigenesis [3].
In conclusion, WWP1 is crucial in various physiological processes. Model-based research, especially using WWP1 KO/CKO mouse models, has revealed its significant roles in cardiac hypertrophy and cancer. These findings provide potential therapeutic targets for treating cardiac diseases and malignancies [1,2,3].
References:
1. Behera, Abhayananda, Reddy, Aramati Bindu Madhava. 2023. WWP1 E3 ligase at the crossroads of health and disease. In Cell death & disease, 14, 853. doi:10.1038/s41419-023-06380-0. https://pubmed.ncbi.nlm.nih.gov/38129384/
2. Zhao, Dingsheng, Zhong, Guohui, Li, Jianwei, Li, Yingxian, Ling, Shukuan. 2021. Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination. In Circulation, 144, 694-711. doi:10.1161/CIRCULATIONAHA.121.054827. https://pubmed.ncbi.nlm.nih.gov/34139860/
3. Lee, Yu-Ru, Chen, Ming, Lee, Jonathan D, Wei, Wenyi, Pandolfi, Pier Paolo. . Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. In Science (New York, N.Y.), 364, . doi:10.1126/science.aau0159. https://pubmed.ncbi.nlm.nih.gov/31097636/
4. Zhi, Xu, Chen, Ceshi. 2011. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. In Cellular and molecular life sciences : CMLS, 69, 1425-34. doi:10.1007/s00018-011-0871-7. https://pubmed.ncbi.nlm.nih.gov/22051607/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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