Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cebpbem1/Cya
Common Name:
Cebpb-KO
Product ID:
S-KO-15990
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cebpb-KO
Strain ID
KOCMP-12608-Cebpb-B6J-VA
Gene Name
Cebpb
Product ID
S-KO-15990
Gene Alias
C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6; NF-M; Nfil6
Background
C57BL/6JCya
NCBI ID
12608
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:88373
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cebpbem1/Cya mice (Catalog S-KO-15990) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000070642
NCBI RefSeq
NM_009883
Target Region
Exon 1
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cebpb, also known as CCAAT/enhancer binding protein (C/EBP), beta, is a crucial transcription factor involved in multiple biological processes. It participates in various pathways such as JAK1-STAT6, FOXO1/NF-κB, and is associated with adipogenesis, immune cell regulation, and stress-related cancer progression [1,4,5]. Genetic models, especially KO/CKO mouse models, are valuable for studying its functions.

In macrophage autophagy-related studies, macrophage Atg5 cKO mice showed reduced cutaneous inflammation in an AD model. Autophagy deficiency led to CEBPB accumulation, which inhibited JAK1-STAT6 pathway activation and M2 macrophage polarization, alleviating AD [1]. In a study on glioblastoma, the CEBPB+ glioblastoma subcluster specifically drove the formation of M2 tumor-associated macrophages, promoting malignancy growth [2]. For CRC, stress-induced epinephrine promoted CRC development through the CEBPB/TRIM2/P53 axis, and CRC cell-derived CCL20 recruited regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling [3,4]. Garcinia cambogia attenuated adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 [5]. IGF2 deficiency promoted liver aging through mitochondrial dysfunction and upregulated CEBPB signaling [6]. In TNBC, glycolysis restriction repressed a specific CEBPB isoform, affecting myeloid-derived suppressor cells and tumor immunity [7]. MSC-induced lncRNA HCP5 promoted stemness and chemo-resistance of gastric cancer through the miR-3619-5p/AMPK/PGC1α/CEBPB axis [8]. In adenoid cystic carcinoma, the NAT10/CEBPB/vimentin axis promoted malignant phenotypes [9].

In conclusion, Cebpb is essential in processes like immune cell regulation, adipogenesis, and cancer-related pathways. The use of KO/CKO mouse models has revealed its role in diseases such as atopic dermatitis, glioblastoma, CRC, liver aging, TNBC, gastric cancer, and adenoid cystic carcinoma, providing insights into potential therapeutic targets. [1-9]

References:

1. Zhu, Yongcheng, Liu, Yunyao, Ma, Yuxiang, He, Yuan, Qiang, Lei. 2023. Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization. In Cell reports, 42, 113430. doi:10.1016/j.celrep.2023.113430. https://pubmed.ncbi.nlm.nih.gov/37963021/

2. Yang, Yongchang, Jin, Xingyu, Xie, Yang, Piao, Yingzhe, Jin, Xun. 2024. The CEBPB+ glioblastoma subcluster specifically drives the formation of M2 tumor-associated macrophages to promote malignancy growth. In Theranostics, 14, 4107-4126. doi:10.7150/thno.93473. https://pubmed.ncbi.nlm.nih.gov/38994023/

3. Zhou, Zili, Shu, Yan, Bao, Haijun, Jian, Chenxing, Shu, Xiaogang. 2022. Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis. In Journal of translational medicine, 20, 262. doi:10.1186/s12967-022-03467-8. https://pubmed.ncbi.nlm.nih.gov/35672760/

4. Wang, Dan, Yang, Li, Yu, Weina, Yuan, Weitang, Zhang, Yi. 2019. Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling. In Journal for immunotherapy of cancer, 7, 215. doi:10.1186/s40425-019-0701-2. https://pubmed.ncbi.nlm.nih.gov/31395078/

5. Han, Joo-Hui, Jang, Keun-Woo, Myung, Chang-Seon. 2021. Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression. In Autophagy, 18, 518-539. doi:10.1080/15548627.2021.1936356. https://pubmed.ncbi.nlm.nih.gov/34101546/

6. Zhou, Xiaohai, Tan, Bowen, Gui, Weiwei, Lin, Xihua, Li, Hong. 2023. IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice. In Molecular medicine (Cambridge, Mass.), 29, 161. doi:10.1186/s10020-023-00752-0. https://pubmed.ncbi.nlm.nih.gov/38017373/

7. Li, Wei, Tanikawa, Takashi, Kryczek, Ilona, Wang, Guobin, Zou, Weiping. 2018. Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer. In Cell metabolism, 28, 87-103.e6. doi:10.1016/j.cmet.2018.04.022. https://pubmed.ncbi.nlm.nih.gov/29805099/

8. Wu, Honglei, Liu, Bin, Chen, Zhaosheng, Li, Guangchun, Zhang, Zhen. 2020. MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer. In Cell death & disease, 11, 233. doi:10.1038/s41419-020-2426-z. https://pubmed.ncbi.nlm.nih.gov/32300102/

9. Fu, Min, Gao, Qian, Xiao, Mian, Li, Sheng-Lin, Ge, Xi-Yuan. 2024. NAT10/CEBPB/vimentin signalling axis promotes adenoid cystic carcinoma malignant phenotypes in vitro. In Oral diseases, 30, 4341-4355. doi:10.1111/odi.14879. https://pubmed.ncbi.nlm.nih.gov/38287502/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest